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PMID: 20061627 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Genome-wide scan of copy number variation in late-onset Alzheimer's disease.

Journal of Alzheimer's disease : JAD ·Vol. 19 ·No. 1 ·2010-00-00 ·Pages 69-77

Heinzen EL, Need AC, Hayden KM, Chiba-Falek O, Roses AD, Strittmatter WJ, Burke JR, Hulette CM, Welsh-Bohmer KA, Goldstein DB

Abstract

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted to identify SNPs that influence disease predisposition. These studies have confirmed the well-known APOE epsilon4 risk allele, identified a novel variant that influences disease risk within the APOE epsilon4 population, found a SNP that modifies the age of disease onset, as well as reported the first sex-linked susceptibility variant. Here we report a genome-wide scan of Alzheimer's disease in a set of 331 cases and 368 controls, extending analyses for the first time to include assessments of copy number variation. In this analysis, no new SNPs show genome-wide significance. We also screened for effects of copy number variation, and while nothing was significant, a duplication in CHRNA7 appears interesting enough to warrant further investigation.

MeSH Terms
Adult Aged Aged, 80 and over Alzheimer Disease/genetics,pathology Apolipoprotein E4/genetics DNA Copy Number Variations/genetics Female Genetic Predisposition to Disease Genetic Variation/genetics Genome-Wide Association Study/methods Humans Male Middle Aged Polymorphism, Single Nucleotide Young Adult
Chemicals
Apolipoprotein E4
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Heinzen Erin L
Institute for Genome Sciences & Policy, Center for Human Genome Variation, Duke University Medical Center, Durham, NC 27708, USA. e.heinzen@duke.edu
Need Anna C
Hayden Kathleen M
Chiba-Falek Ornit
Roses Allen D
Strittmatter Warren J
Burke James R
Hulette Christine M
Welsh-Bohmer Kathleen A
Goldstein David B
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Article Info
Journal
Journal of Alzheimer's disease : JAD
Abbr.
J Alzheimers Dis
ISSN
1875-8908
Published
2010-00-00
Pages
69-77
Language
English
Region
Netherlands
NLM ID
9814863
PMCID
PMC2883723
Subset
IM
Grants
NIA NIH HHS · P30 AG028377 · United States
NIA NIH HHS · P30 AG028377-03 · United States
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