Alzheimer disease: New light on an old CLU.

Nature reviews. Neurology ·Vol. 6 ·No. 1 ·2010-01-00 ·Pages 11-3

Bertram L, Tanzi RE

Abstract

暂无摘要

MeSH Terms

Alzheimer Disease/genetics Clusterin/genetics Genetic Predisposition to Disease Genome-Wide Association Study Humans Monomeric Clathrin Assembly Proteins/genetics Multicenter Studies as Topic Receptors, Complement 3b/genetics Risk Factors

Chemicals

CLU protein, human CR1 protein, human Clusterin Monomeric Clathrin Assembly Proteins PICALM protein, human Receptors, Complement 3b

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bertram Lars

Tanzi Rudolph E

References (9)

9 references, click to expand

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.
Nat Genet. 2009 Oct;41(10):1088-93 PMID: 19734902
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.
Am J Hum Genet. 2008 Nov;83(5):623-32 PMID: 18976728
Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses.
Nat Rev Neurosci. 2008 Oct;9(10):768-78 PMID: 18802446
Cerebrovascular transport of Alzheimer's amyloid beta and apolipoproteins J and E: possible anti-amyloidogenic role of the blood-brain barrier.
Life Sci. 1996;59(18):1483-97 PMID: 8890929
Candidate single-nucleotide polymorphisms from a genomewide association study of Alzheimer disease.
Arch Neurol. 2008 Jan;65(1):45-53 PMID: 17998437
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.
Nat Genet. 2009 Oct;41(10):1094-9 PMID: 19734903
Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice.
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10837-42 PMID: 12119423
GAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriers.
Neuron. 2007 Jun 7;54(5):713-20 PMID: 17553421
Evidence for CALM in directing VAMP2 trafficking.
Traffic. 2008 Mar;9(3):417-29 PMID: 18182011

Article Info

Journal

Nature reviews. Neurology

Abbr.

Nat Rev Neurol

ISSN

1759-4766

DOI

10.1038/nrneurol.2009.213

Published

2010-01-00

Pages

11-3

Language

English

Region

England

NLM ID

101500072

PMCID

PMC2860389

Subset

Grants

NIMH NIH HHS · R37 MH060009 · United States

NIMH NIH HHS · R37 MH060009-10 · United States

Corrections

ErratumIn

External Links

PubMed source DOI: 10.1038/nrneurol.2009.213 PMC Full Text View journal details

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