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题目:: Family history of cancer and risk of pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
作者:: Jacobs(Eric J),Chanock(Stephen J),Fuchs(Charles S),Lacroix(Andrea),McWilliams(Robert R),Steplowski(Emily),Stolzenberg-Solomon(Rachael Z),Arslan(Alan A),Bueno-de-Mesquita(H Bas),Gross(Myron),Helzlsouer(Kathy),Petersen(Gloria),Zheng(Wei),Agalliu(Ilir),Allen(Naomi E),Amundadottir(Laufey),Boutron-Ruault(Marie-Christine),Buring(Julie E),Canzian(Federico),Clipp(Sandra),Dorronsoro(Miren),Gaziano(J Michael),Giovannucci(Edward L),Hankinson(Susan E),Hartge(Patricia),Hoover(Robert N),Hunter(David J),Jacobs(Kevin B),Jenab(Mazda),Kraft(Peter),Kooperberg(Charles),Lynch(Shannon M),Sund(Malin),Mendelsohn(Julie B),Mouw(Tracy),Newton(Christina C),Overvad(Kim),Palli(Domenico),Peeters(Petra H M),Rajkovic(Aleksandar),Shu(Xiao-Ou),Thomas(Gilles),Tobias(Geoffrey S),Trichopoulos(Dimitrios),Virtamo(Jarmo),Wactawski-Wende(Jean),Wolpin(Brian M),Yu(Kai),Zeleniuch-Jacquotte(Anne)
状态:: 发布时间2010-07-27 , 更新时间 2016-12-03
期刊:: Int J Cancer
摘要:: A family history of pancreatic cancer has consistently been associated with increased risk of pancreatic cancer. However, uncertainty remains about the strength of this association. Results from previous studies suggest a family history of select cancers (i.e., ovarian, breast and colorectal) could also be associated, although not as strongly, with increased risk of pancreatic cancer. We examined the association between a family history of 5 types of cancer (pancreas, prostate, ovarian, breast and colorectal) and risk of pancreatic cancer using data from a collaborative nested case-control study conducted by the Pancreatic Cancer Cohort Consortium. Cases and controls were from cohort studies from the United States, Europe and China, and a case-control study from the Mayo Clinic. Analyses of family history of pancreatic cancer included 1,183 cases and 1,205 controls. A family history of pancreatic cancer in a parent, sibling or child was associated with increased risk of pancreatic cancer [multivariate-adjusted odds ratios (ORs) = 1.76, 95% confidence interval (CI) = 1.19-2.61]. A family history of prostate cancer was also associated with increased risk (OR = 1.45, 95% CI = 1.12-1.89). There were no statistically significant associations with a family history of ovarian cancer (OR = 0.82, 95% CI = 0.52-1.31), breast cancer (OR = 1.21, 95% CI = 0.97-1.51) or colorectal cancer (OR = 1.17, 95% CI = 0.93-1.47). Our results confirm a moderate sized association between a family history of pancreatic cancer and risk of pancreatic cancer and also provide evidence for an association with a family history of prostate cancer worth further study.
语言:: eng
DOI:

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