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题目:: Novel role for the transient receptor potential channel TRPM2 in prostate cancer cell proliferation.
作者:: Zeng(X),Sikka(S C),Huang(L),Sun(C),Xu(C),Jia(D),Abdel-Mageed(A B),Pottle(J E),Taylor(J T),Li(M)
状态:: 发布时间2010-05-13 , 更新时间 2014-12-04
期刊:: Prostate Cancer Prostatic Dis
摘要:: We have identified a novel function for a member of the transient receptor potential (TRP) protein super-family, TRPM2, in prostate cancer cell proliferation. TRPM2 encodes a non-selective cation-permeable ion channel. We found that selectively knocking down TRPM2 with the small interfering RNA technique inhibited the growth of prostate cancer cells but not of non-cancerous cells. The subcellular localization of this protein is also remarkably different between cancerous and non-cancerous cells. In BPH-1 (benign), TRPM2 protein is homogenously located near the plasma membrane and in the cytoplasm, whereas in the cancerous cells (PC-3 and DU-145), a significant amount of the TRPM2 protein is located in the nuclei in a clustered pattern. Furthermore, we have found that TRPM2 inhibited nuclear ADP-ribosylation in prostate cancer cells. However, TRPM2 knockdown-induced inhibition of proliferation is independent of the activity of poly(ADP-ribose) polymerases. We conclude that TRPM2 is essential for prostate cancer cell proliferation and may be a potential target for the selective treatment of prostate cancer.
语言:: eng
DOI:

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