Abstract
Hospital acquired infections with respiratory syncytial virus are a major problem. The virus is spread predominantly by infected nasal secretions and we investigated whether we could reduce its incidence by cohorting babies on each ward into designated areas and encouraging staff and parents to wash their hands. We examined the incidence of hospital acquired infection due to respiratory syncytial virus in all children less than 2 years old and in those with congenital heart disease. In 1986-7, before any intervention, 18 (4.2%) of 425 hospitalised children less than 2 years old developed hospital acquired infection due to respiratory syncytial virus. In 1987-8, after intervention, five (0.6%) of 840 children developed hospital acquired infection but there were fewer ward admissions with community acquired infections due to the virus. In 1988-9, when there were more community acquired infections than 1986-7, six (1.1%) of 552 children developed hospital acquired infection. In 1986-7, eight (34.8%) of 23 children less than 2 years old with congenital heart disease developed hospital acquired infection due to respiratory syncytial virus; all eight were among 11 children with congenital heart disease hospitalised for more than 14 days. In 1987-8, one (3.3%) of 30 children with congenital heart disease developed hospital acquired infection due to respiratory syncytial virus and in 1988-9 there was one (2.1%) case out of 47 children with congenital heart disease. Handwashing and cohorting significantly reduce the incidence of nosocomial respiratory syncytial virus infection.
MeSH Terms
Cohort Studies
Cross Infection/prevention & control,transmission
Hand Disinfection
Heart Defects, Congenital/complications
Humans
Infant
Prospective Studies
Respiratory Syncytial Viruses
Respirovirus Infections/prevention & control,transmission
Risk Factors
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Isaacs D
Departmetn of Paediatrics, John Radcliffe Hospital, Oxford.
Dickson H
O'Callaghan C
Sheaves R
Winter A
Moxon E R
References (14)
14 references, click to expand
-
Respiratory syncytial viral infection in children with compromised immune function.
N Engl J Med. 1986 Jul 10;315(2):77-81
PMID: 3724802
-
The use of eye-nose goggles to control nosocomial respiratory syncytial virus infection.
JAMA. 1986 Nov 21;256(19):2706-8
PMID: 3773177
-
Prevention of nosocomial respiratory syncytial virus infections through compliance with glove and gown isolation precautions.
N Engl J Med. 1987 Aug 6;317(6):329-34
PMID: 3600729
-
Cell-mediated cytotoxic response to respiratory syncytial virus in infants with bronchiolitis.
Lancet. 1987 Oct 3;2(8562):769-71
PMID: 2888988
-
Role of respiratory syncytial virus in early hospitalizations for respiratory distress of young infants with cystic fibrosis.
J Pediatr. 1988 Nov;113(5):826-30
PMID: 3183835
-
Comparative virulence of respiratory syncytial virus subgroups A and B.
Lancet. 1989 Apr 8;1(8641):777-8
PMID: 2564579
-
Transmission of rhinovirus colds by self-inoculation.
N Engl J Med. 1973 Jun 28;288(26):1361-4
PMID: 4350527
-
Nosocomial respiratory syncytial virus infections.
N Engl J Med. 1975 Dec 25;293(26):1343-6
PMID: 1186836
-
Respiratory syncytial virus infections in infants: quantitation and duration of shedding.
J Pediatr. 1976 Jul;89(1):11-5
PMID: 180274
-
Possible transmission by fomites of respiratory syncytial virus.
J Infect Dis. 1980 Jan;141(1):98-102
PMID: 7365274
-
Intracranial pressure. Sequential measurements in full-term and preterm infants.
Am J Dis Child. 1981 Jun;135(6):521-4
PMID: 7234786
-
Modes of transmission of respiratory syncytial virus.
J Pediatr. 1981 Jul;99(1):100-3
PMID: 7252646
-
Respiratory syncytial viral infection in infants with congenital heart disease.
N Engl J Med. 1982 Aug 12;307(7):397-400
PMID: 7088112
-
Guideline for isolation precautions in hospitals.
Infect Control. 1983 Jul-Aug;4(4 Suppl):245-325
PMID: 6309693