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PMID: 20000552 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review

Organic chemistry and biology: chemical biology through the eyes of collaboration.

The Journal of organic chemistry ·Vol. 74 ·No. 24 ·2009-12-18 ·Pages 9245-64

Hruby VJ

Abstract

From a scientific perspective, efforts to understand biology including what constitutes health and disease has become a chemical problem. However, chemists and biologists "see" the problems of understanding biology from different perspectives, and this has retarded progress in solving the problems especially as they relate to health and disease. This suggests that close collaboration between chemists and biologists is not only necessary but essential for progress in both the biology and chemistry that will provide solutions to the global questions of biology. This perspective has directed my scientific efforts for the past 45 years, and in this overview I provide my perspective of how the applications of synthetic chemistry, structural design, and numerous other chemical principles have intersected in my collaborations with biologists to provide new tools, new science, and new insights that were only made possible and fruitful by these collaborations.

MeSH Terms
Biology/methods,trends Chemistry, Organic/methods,trends Chemistry, Pharmaceutical/methods,trends Drug Design International Cooperation Organic Chemicals/chemical synthesis,chemistry
Chemicals
Organic Chemicals
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Hruby Victor J
Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, USA. hruby@u.arizona.edu
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Article Info
Journal
The Journal of organic chemistry
Abbr.
J Org Chem
ISSN
1520-6904
DOI
10.1021/jo901767e
Email
hruby@u.arizona.edu
Published
2009-12-18
Pages
9245-64
Language
English
Region
United States
NLM ID
2985193R
PMCID
PMC3041175
Subset
IM
Grants
NIDA NIH HHS · R01 DA013449-10 · United States
NIDDK NIH HHS · R01 DK017420 · United States
NCI NIH HHS · R01 CA097360 · United States
NIDDK NIH HHS · R01 DK017420-34 · United States
NCI NIH HHS · R01 CA097360-08 · United States
NIDA NIH HHS · R01 DA013449 · United States
NIDA NIH HHS · P01 DA006284 · United States
NIDA NIH HHS · P01 DA006284-20 · United States
External Links
PubMed source DOI: 10.1021/jo901767e PMC Full Text View journal details
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