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PMID: 19996368 Published · ppublish English Journal Article Review

The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters.

Physiology (Bethesda, Md.) ·Vol. 24 ·2009-12-00 ·Pages 377-86

Forrest LR, Rudnick G

Abstract

Crystal structures of the bacterial amino acid transporter LeuT have provided the basis for understanding the conformational changes associated with substrate translocation by a multitude of transport proteins with the same fold. Biochemical and modeling studies led to a "rocking bundle" mechanism for LeuT that was validated by subsequent transporter structures. These advances suggest how coupled solute transport might be defined by the internal symmetry of proteins containing inverted structural repeats.

MeSH Terms
Binding Sites Escherichia coli Proteins/metabolism Ion Transport/physiology Ions/metabolism Membrane Transport Proteins/metabolism Protein Conformation
Chemicals
Escherichia coli Proteins Ions Membrane Transport Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Forrest Lucy R
Computational Structural Biology, Max Planck Institute for Biophysics, Frankfurt, Germany.
Rudnick Gary
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Article Info
Journal
Physiology (Bethesda, Md.)
Abbr.
Physiology (Bethesda)
ISSN
1548-9221
DOI
10.1152/physiol.00030.2009
Published
2009-12-00
Pages
377-86
Language
English
Region
United States
NLM ID
101208185
PMCID
PMC3012352
Subset
IM
Grants
NIDA NIH HHS · R01 DA007259 · United States
NIDA NIH HHS · R01 DA007259-16 · United States
NIDA NIH HHS · R01 DA008213 · United States
NIGMS NIH HHS · R01 GM075347 · United States
External Links
PubMed source DOI: 10.1152/physiol.00030.2009 PMC Full Text View journal details
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