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PMID: 1997419 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Monoclonal antibody immunotherapy in nude mice persistently infected with Cryptosporidium parvum.

Infection and immunity ·Vol. 59 ·No. 3 ·1991-03-00 ·Pages 1172-6

Bjorneby JM, Hunsaker BD, Riggs MW, Perryman LE

Abstract

Three groups of congenitally athymic nude mice were persistently infected following oral administration of 2 x 10(7) Cryptosporidium parvum oocysts. Two groups were treated once daily for 10 days with either neutralizing monoclonal antibody (MAb) 17.41 or an isotype control MAb. The third group received no treatment. Intestinal-infection scores were significantly decreased in nude mice treated with MAb 17.41 compared with isotype control MAb-treated and nontreated control groups (P less than 0.005). Biliary and pancreatic cryptosporidial-infection scores were similar for the MAb 17.41-treated and isotype control MAb-treated groups (P greater than 0.05).

MeSH Terms
Animals Antibodies, Monoclonal/therapeutic use Antibodies, Protozoan/therapeutic use Antigens, Protozoan/immunology Blotting, Western Common Bile Duct/parasitology Cryptosporidiosis/pathology,therapy Female Immunotherapy Intestinal Diseases, Parasitic/parasitology,therapy Intestines/parasitology Mice Mice, Nude
Chemicals
Antibodies, Monoclonal Antibodies, Protozoan Antigens, Protozoan
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bjorneby J M
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
Hunsaker B D
Riggs M W
Perryman L E
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.59.3.1172-1176.1991
Published
1991-03-00
Pages
1172-6
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC258384
Subset
IM
Grants
NIAID NIH HHS · AI-25731 · United States
External Links
PubMed source DOI: 10.1128/iai.59.3.1172-1176.1991 PMC Full Text View journal details
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