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PMID: 19959720 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Dietary fructose inhibits intestinal calcium absorption and induces vitamin D insufficiency in CKD.

Journal of the American Society of Nephrology : JASN ·Vol. 21 ·No. 2 ·2010-02-00 ·Pages 261-71

Douard V, Asgerally A, Sabbagh Y, Sugiura S, Shapses SA, Casirola D, Ferraris RP

Abstract

Renal disease leads to perturbations in calcium and phosphate homeostasis and vitamin D metabolism. Dietary fructose aggravates chronic kidney disease (CKD), but whether it also worsens CKD-induced derangements in calcium and phosphate homeostasis is unknown. Here, we fed rats diets containing 60% glucose or fructose for 1 mo beginning 6 wk after 5/6 nephrectomy or sham operation. Nephrectomized rats had markedly greater kidney weight, blood urea nitrogen, and serum levels of creatinine, phosphate, and calcium-phosphate product; dietary fructose significantly exacerbated all of these outcomes. Expression and activity of intestinal phosphate transporter, which did not change after nephrectomy or dietary fructose, did not correlate with hyperphosphatemia in 5/6-nephrectomized rats. Intestinal transport of calcium, however, decreased with dietary fructose, probably because of fructose-mediated downregulation of calbindin 9k. Serum calcium levels, however, were unaffected by nephrectomy and diet. Finally, only 5/6-nephrectomized rats that received dietary fructose demonstrated marked reductions in 25-hydroxyvitamin D(3) and 1,25-dihydroxyvitamin D(3) levels, despite upregulation of 1alpha-hydroxylase. In summary, excess dietary fructose inhibits intestinal calcium absorption, induces marked vitamin D insufficiency in CKD, and exacerbates other classical symptoms of the disease. Future studies should evaluate the relevance of monitoring fructose consumption in patients with CKD.

MeSH Terms
25-Hydroxyvitamin D3 1-alpha-Hydroxylase/metabolism Animals Bone Density Calcifediol/metabolism Calcitriol/metabolism Calcium/metabolism Chronic Disease Dietary Carbohydrates/adverse effects,pharmacology Disease Models, Animal Fructose/adverse effects,pharmacology Glucose/pharmacology Intestinal Absorption/drug effects Kidney/metabolism,surgery Kidney Diseases/complications,metabolism Male Nephrectomy Phosphates/metabolism Rats Rats, Sprague-Dawley Vitamin D Deficiency/etiology,metabolism
Chemicals
Dietary Carbohydrates Phosphates Fructose 25-Hydroxyvitamin D3 1-alpha-Hydroxylase Calcitriol Glucose Calcifediol Calcium
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Douard Veronique
Department of Pharmacology and Physiology, UMDNJ-New Jersey Medical School, Newark, NJ 07101-1709, USA.
Asgerally Abbas
Sabbagh Yves
Sugiura Shozo
Shapses Sue A
Casirola Donatella
Ferraris Ronaldo P
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Article Info
Journal
Journal of the American Society of Nephrology : JASN
Abbr.
J Am Soc Nephrol
ISSN
1533-3450
DOI
10.1681/ASN.2009080795
Published
2010-02-00
Epub
2009-00-03
Pages
261-71
Language
English
Region
United States
NLM ID
9013836
PMCID
PMC2834550
Subset
IM
Grants
NIA NIH HHS · R01 AG012161 · United States
NIDDK NIH HHS · R21 DK075617 · United States
NIDDK NIH HHS · DK075617 · United States
NIA NIH HHS · AG-12161 · United States
External Links
PubMed source DOI: 10.1681/ASN.2009080795 PMC Full Text View journal details
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