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PMID: 19933149 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Nonallelic transvection of multiple imprinted loci is organized by the H19 imprinting control region during germline development.

Genes & development ·Vol. 23 ·No. 22 ·2009-11-15 ·Pages 2598-603

Sandhu KS, Shi C, Sjölinder M, Zhao Z, Göndör A, Liu L, Tiwari VK, Guibert S, Emilsson L, Imreh MP, Ohlsson R

Abstract

Recent observations highlight that the mammalian genome extensively communicates with itself via long-range chromatin interactions. The causal link between such chromatin cross-talk and epigenetic states is, however, poorly understood. We identify here a network of physically juxtaposed regions from the entire genome with the common denominator of being genomically imprinted. Moreover, CTCF-binding sites within the H19 imprinting control region (ICR) not only determine the physical proximity among imprinted domains, but also transvect allele-specific epigenetic states, identified by replication timing patterns, to interacting, nonallelic imprinted regions during germline development. We conclude that one locus can directly or indirectly pleiotropically influence epigenetic states of multiple regions on other chromosomes with which it interacts.

MeSH Terms
Alleles Animals Cells, Cultured Embryonic Stem Cells Female Gene Expression Regulation, Developmental Genomic Imprinting/genetics Germ Cells/growth & development,metabolism Male Mice Mice, Inbred C57BL RNA, Long Noncoding RNA, Untranslated
Chemicals
H19 long non-coding RNA RNA, Long Noncoding RNA, Untranslated
Authors & Affiliations
11 authors, click to expand affiliations / ORCID
Sandhu Kuljeet Singh
Department of Development and Genetics, Evolution Biology Centre, Uppsala University, S-752 36 Uppsala, Sweden.
Shi Chengxi
Sjölinder Mikael
Zhao Zhihu
Göndör Anita
Liu Liang
Tiwari Vijay K
Guibert Sylvain
Emilsson Lina
Imreh Marta P
Ohlsson Rolf
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Article Info
Journal
Genes & development
Abbr.
Genes Dev
ISSN
1549-5477
DOI
10.1101/gad.552109
Published
2009-11-15
Pages
2598-603
Language
English
Region
United States
NLM ID
8711660
PMCID
PMC2779760
Subset
IM
External Links
PubMed source DOI: 10.1101/gad.552109 PMC Full Text View journal details
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