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PMID: 19932099 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Modularity and design principles in the sea urchin embryo gene regulatory network.

FEBS letters ·Vol. 583 ·No. 24 ·2009-12-17 ·Pages 3948-58

Peter IS, Davidson EH

Abstract

The gene regulatory network (GRN) established experimentally for the pre-gastrular sea urchin embryo provides causal explanations of the biological functions required for spatial specification of embryonic regulatory states. Here we focus on the structure of the GRN which controls the progressive increase in complexity of territorial regulatory states during embryogenesis; and on the types of modular subcircuits of which the GRN is composed. Each of these subcircuit topologies executes a particular operation of spatial information processing. The GRN architecture reflects the particular mode of embryogenesis represented by sea urchin development. Network structure not only specifies the linkages constituting the genomic regulatory code for development, but also indicates the various regulatory requirements of regional developmental processes.

MeSH Terms
Animals Embryo, Nonmammalian/metabolism Gastrula/metabolism Gene Expression Regulation, Developmental Gene Regulatory Networks Models, Genetic Sea Urchins/embryology,genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Peter Isabelle S
California Institute of Technology, Division of Biology, Pasadena, CA 91125, USA. ipeter@caltech.edu
Davidson Eric H
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Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
1873-3468
DOI
10.1016/j.febslet.2009.11.060
Email
ipeter@caltech.edu
Published
2009-12-17
Pages
3948-58
Language
English
Region
England
NLM ID
0155157
PMCID
PMC2810318
Subset
IM
Grants
NICHD NIH HHS · P01 HD037105 · United States
NICHD NIH HHS · P01 HD037105-11A1 · United States
NICHD NIH HHS · HD37105 · United States
External Links
PubMed source DOI: 10.1016/j.febslet.2009.11.060 PMC Full Text View journal details
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