Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 9 ·1977-09-00 ·Pages 4029-32

Devynck MA, Pernollet MG, Matthews PG, Khosla MC, Bumpus FM, Meyer P

Abstract

The specific binding of angiotensin II and des-Asp1-angiotensin II ("angiotensin III") III") to rat adrenals was studied with the use of the tritiated peptides. The binding sites having maximal affinity for angiotensin II were characterized by an equilibrium dissociation constant of 3.3 to 5.2 X 10(-9) M. Angiotensin III was able to interact with these sites, and also with a class of sites with very high affinity, characterized by an equilibrium dissociation constant of 1 to 2 X 10(-10) M. These sites exhibited a greater affinity for the heptapeptide angiotensin III than for the octapeptide angiotensin II. These findings, together with the known potent aldosterone stimulating effect of angiotensin III and its presence in rat plasma, suggest that this heptapeptide could be the physiologically important steroidogenic angiotensin in this species.

MeSH Terms

Adrenal Glands/metabolism Angiotensin II/analogs & derivatives,metabolism Angiotensin III/metabolism Animals Kinetics Rats Receptors, Angiotensin/metabolism Receptors, Cell Surface/metabolism

Chemicals

Receptors, Angiotensin Receptors, Cell Surface Angiotensin II Angiotensin III

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Devynck M A

Pernollet M G

Matthews P G

Khosla M C

Bumpus F M

Meyer P

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23 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.9.4029

Published

1977-09-00

Pages

4029-32

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431830

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.9.4029 PMC Full Text View journal details

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Specific receptors for des-Asp1-angiotensin II (("angiotensin III") in rat adrenals.

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