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PMID: 19871692 Published · ppublish English Journal Article

RENAL EFFECTS OF HEMOGLOBIN INFUSIONS IN DOGS IN HEMORRHAGIC SHOCK.

The Journal of experimental medicine ·Vol. 86 ·No. 6 ·1947-11-30 ·Pages 477-87

Hamilton PB, Hiller A, Van Slyke DD

Abstract

The immediate effects of treating hemorrhagic shock in dogs by replacing lost blood with 7 per cent hemoglobin solution were favorable, both on renal function and on general condition. However, subsequent transitory depression of the urea clearance for several days, shown by some of the treated animals, but not by untreated bled controls, indicates sufficient possibility of renal damage by the hemoglobin solution to prevent its recommendation at present as a blood substitute.

Keywords
HEMOGLOBIN INFUSION/renal effects SHOCK/hemorrhagic and Hb transfusion
MeSH Terms
Animals Blood Substitutes Blood Transfusion Dogs Hemoglobins Kidney Platelet Transfusion Shock Shock, Hemorrhagic
Chemicals
Blood Substitutes Hemoglobins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hamilton P B
United States Navy Research Unit at the Hospital of The Rockefeller Institute for Medical Research.
Hiller A
Van Slyke D D
References (3)
3 references, click to expand
  1. CARBOHYDRATE METABOLISM IN NEPHRITIS.
    J Clin Invest. 1925 Feb;1(3):247-72 PMID: 16693651
  2. STUDIES OF UREA EXCRETION. II: Relationship Between Urine Volume and the Rate of Urea Excretion by Normal Adults.
    J Clin Invest. 1928 Dec;6(3):427-65 PMID: 16693839
  3. PREPARATION OF HEMOGLOBIN SOLUTIONS FOR INTRAVENOUS INFUSION.
    J Exp Med. 1947 Nov 30;86(6):455-63 PMID: 19871690
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1947-11-30
Pages
477-87
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2135756
Subset
OM
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