PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS.

The Journal of experimental medicine ·Vol. 80 ·No. 4 ·1944-10-01 ·Pages 299-307

Kabat EA, Kaiser H, Sikorski H

Abstract

1. Methods for preparing small amounts of Type I meningococcal polysaccharide which are electrophoretically homogeneous and contain only traces of other immunologically reactive material are given. 2. These polysaccharides are very poor antigens in man but in a small number of instances definite amounts of precipitin and protective antibody were formed. 3. The significance of these findings is discussed.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kabat E A

Department of Neurology and the Electrophoresis Laboratory, College of Physicians and Surgeons, Columbia University, and the Neurological Institute of New York.

Kaiser H

Sikorski H

References (8)

8 references, click to expand

STUDIES ON MENINGOCOCCUS INFECTION : VIII. THE TYPE I SPECIFIC SUBSTANCE.
J Exp Med. 1935 May 31;61(6):753-69 PMID: 19870389
THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA.
J Exp Med. 1935 Mar 31;61(4):559-62 PMID: 19870379
THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS : A REVISION OF METHODS AND DATA.
J Exp Med. 1936 Sep 30;64(4):559-72 PMID: 19870553
REACTIONS OF HUMAN SUBJECTS TO THE INJECTION OF PURIFIED TYPE SPECIFIC PNEUMOCOCCUS POLYSACCHARIDES.
J Clin Invest. 1938 Jul;17(4):479-88 PMID: 16694595
STUDIES ON SERUM PROTEINS. I. IDENTIFICATION OF A SINGLE SERUM GLOBULIN BY IMMUNOLOGICAL MEANS. ITS DISTRIBUTION IN THE SERA OF NORMAL INDIVIDUALS AND OF PATIENTS WITH CIRRHOSIS OF THE LIVER AND WITH CHRONIC GLOMERULONEPHRITIS.
J Clin Invest. 1937 Nov;16(6):921-31 PMID: 16694538
QUANTITATIVE MICRO-ESTIMATION OF ANTIBODIES IN THE SERA OF MAN AND OTHER ANIMALS.
Science. 1943 Apr 30;97(2522):405-6 PMID: 17832515
SPECIFIC ANTIBODY RESPONSE OF HUMAN SUBJECTS TO INTRACUTANEOUS INJECTION OF PNEUMOCOCCUS PRODUCTS.
J Exp Med. 1932 May 31;55(6):853-65 PMID: 19870036
CUTANEOUS REACTIONS IN PNEUMONIA. THE DEVELOPMENT OF ANTIBODIES FOLLOWING THE INTRADERMAL INJECTION OF TYPE-SPECIFIC POLYSACCHARIDE.
J Exp Med. 1930 Sep 30;52(4):573-85 PMID: 19869789

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.80.4.299

Published

1944-10-01

Pages

299-307

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2135467

External Links

PubMed source DOI: 10.1084/jem.80.4.299 PMC Full Text View journal details

Analysis Services

PREPARATION OF THE TYPE-SPECIFIC POLYSACCHARIDE OF THE TYPE I MENINGOCOCCUS AND A STUDY OF ITS EFFECTIVENESS AS AN ANTIGEN IN HUMAN BEINGS.

Contact

WeChat Official Account