THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD : III. IMMUNOLOGICAL PROPERTIES OF THE C-REACTIVE PROTEIN AND ITS DIFFERENTIATION FROM NORMAL BLOOD PROTEINS.
The C-reactive protein present in the albumin fraction of the serum of patients during certain acute bacterial infections is highly antigenic upon injection into rabbits. The antiserum thus prepared reacts specifically with this protein and does not react with the proteins of normal human serum. Immunological specificity has been demonstrated by both precipitin and complement-fixation tests. Antiserum prepared in rabbits to the C-reactive protein from human sources also reacts specifically with the similar protein in the serum of monkeys acutely ill with experimental pneumococcus infection. By means of immunological reactions it is possible to detect amounts of reactive protein which are too small to yield a visible precipitate in tests with the C polysaccharide. Certain of the properties are discussed which distinguish the C-reactive protein from the proteins of normal human serum.
12 references, click to expand
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IMMUNOLOGICAL STUDIES OF A HEAT-STABLE SUBSTANCE ISOLATED FROM TISSUES INFECTED WITH VACCINE VIRUS.J Exp Med. 1938 Feb 28;67(3):361-7 PMID: 19870726
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THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD : I. DISTRIBUTION OF THE REACTIVE PROTEIN IN PATIENTS' SERA AND THE EFFECT OF CALCIUM ON THE FLOCCULATION REACTION WITH C POLYSACCHARIDE OF PNEUMOCOCCUS.J Exp Med. 1941 Jan 31;73(2):173-82 PMID: 19871070
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IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS : VI. ISOLATION OF A HEAT-STABLE, SEROLOGICALLY ACTIVE SUBSTANCE FROM TISSUES INFECTED WITH VACCINE VIRUS.J Exp Med. 1937 Jan 31;65(2):243-9 PMID: 19870598
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A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. INDEPENDENCE OF ANTI-SOLUBLE SUBSTANCE ANTIBODIES AND NEUTRALIZING ANTIBODIES, AND THE ROLE OF SOLUBLE ANTIGEN AND INACTIVE VIRUS IN IMMUNITY TO INFECTION.J Exp Med. 1940 Sep 30;72(4):389-405 PMID: 19871032
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INFECTIOUS MYXOMATOSIS OF RABBITS : II. DEMONSTRATION OF A SECOND SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE.J Exp Med. 1940 Jul 31;72(2):129-38 PMID: 19871012
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STUDIES ON THE SOMATIC C POLYSACCHARIDE OF PNEUMOCOCCUS : I. CUTANEOUS AND SEROLOGICAL REACTIONS IN PNEUMONIA.J Exp Med. 1937 Jan 1;65(1):59-73 PMID: 19870591
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CHEMICAL AND IMMUNOLOGICAL PROPERTIES OF A SPECIES-SPECIFIC CARBOHYDRATE OF PNEUMOCOCCI.J Exp Med. 1930 Nov 30;52(6):895-900 PMID: 19869812
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STUDIES ON THE SOMATIC C POLYSACCHARIDE OF PNEUMOCOCCUS : II. THE PRECIPITATION REACTION IN ANIMALS WITH EXPERIMENTALLY INDUCED PNEUMOCOCCIC INFECTION.J Exp Med. 1937 Jan 1;65(1):75-89 PMID: 19870592
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SEROLOGICAL REACTIONS IN PNEUMONIA WITH A NON-PROTEIN SOMATIC FRACTION OF PNEUMOCOCCUS.J Exp Med. 1930 Sep 30;52(4):561-71 PMID: 19869788
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INFECTIOUS MYXOMATOSIS OF RABBITS : PREPARATION OF ELEMENTARY BODIES AND STUDIES OF SEROLOGICALLY ACTIVE MATERIALS ASSOCIATED WITH THE DISEASE.J Exp Med. 1937 Jun 30;66(1):1-14 PMID: 19870643
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THE OCCURRENCE DURING ACUTE INFECTIONS OF A PROTEIN NOT NORMALLY PRESENT IN THE BLOOD : II. ISOLATION AND PROPERTIES OF THE REACTIVE PROTEIN.J Exp Med. 1941 Jan 31;73(2):183-90 PMID: 19871071
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SPECIFIC AND NON-SPECIFIC POLYSACCHARIDES OF TYPE IV PNEUMOCOCCUS.J Exp Med. 1931 Apr 30;53(5):625-39 PMID: 19869869
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