PROPERTIES OF THE TYPE SPECIFIC PROTEINS OF ANTIPNEUMOCOCCUS SERA : I. THE MOUSE PROTECTIVE VALUE OF TYPE I SERA WITH REFERENCE TO THE PRECIPITIN CONTENT.

The Journal of experimental medicine ·Vol. 66 ·No. 4 ·1937-09-30 ·Pages 413-24

Goodner K, Horsfall FL

Abstract

The ability to carry out with some measure of precision mouse protection tests for the estimation of potency of antipneumococcus sera has made possible the correlation of the protective potency with the amount of specifically precipitable protein. With antipneumococcus rabbit sera these protective ratios are relatively constant and higher than those with immune horse serum. Type I antipneumococcus horse sera, on the other hand, show no such constancy but fall into two groups; and there is as yet no simple method for determining to which group a serum belongs.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Goodner K

Hospital of The Rockefeller Institute for Medical Research.

Horsfall F L

References (9)

9 references, click to expand

SPECIFIC PRECIPITATION AND MOUSE PROTECTION IN TYPE I ANTIPNEUMOCOCCUS SERA.
J Exp Med. 1930 Sep 30;52(4):477-83 PMID: 19869781
IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS : IV. STATISTICAL STUDIES OF ELEMENTARY BODIES IN RELATION TO INFECTION AND AGGLUTINATION.
J Exp Med. 1936 Aug 31;64(3):439-52 PMID: 19870546
THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY : II. CONDITIONS FOR QUANTITATIVE PRECIPITATION OF ANTIBODY IN HORSE SERA.
J Exp Med. 1935 Mar 31;61(4):559-62 PMID: 19870379
LIPIDS AND IMMUNOLOGICAL REACTIONS : III. LIPID CONTENT OF SPECIFIC PRECIPITATES FROM TYPE I ANTIPNEUMOCOCCUS SERA.
J Exp Med. 1936 Sep 30;64(4):583-99 PMID: 19870555
THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : I. THE QUANTITATIVE ASPECTS OF THE MOUSE PROTECTION TEST.
J Exp Med. 1935 Aug 31;62(3):359-74 PMID: 19870421
THE SPECIFIC POLYSACCHARIDES OF TYPES I, II, AND III PNEUMOCOCCUS : A REVISION OF METHODS AND DATA.
J Exp Med. 1936 Sep 30;64(4):559-72 PMID: 19870553
THE MOLECULAR WEIGHT OF ANTIBODIES.
J Exp Med. 1937 Feb 28;65(3):393-414 PMID: 19870608
THE PROTECTIVE ACTION OF TYPE I ANTIPNEUMOCOCCUS SERUM IN MICE : V. THE EFFECT OF ADDED LIPIDS ON THE PROTECTIVE MECHANISM.
J Exp Med. 1936 Aug 31;64(3):377-83 PMID: 19870542
QUANTITATIVE STUDIES ON ANTIBODY PURIFICATION : I. THE DISSOCIATION OF PRECIPITATES FORMED BY PNEUMOCOCCUS SPECIFIC POLYSACCHARIDES AND HOMOLOGOUS ANTIBODIES.
J Exp Med. 1936 Jul 31;64(2):161-72 PMID: 19870527

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.66.4.413

Published

1937-09-30

Pages

413-24

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2133582

External Links

PubMed source DOI: 10.1084/jem.66.4.413 PMC Full Text View journal details

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PROPERTIES OF THE TYPE SPECIFIC PROTEINS OF ANTIPNEUMOCOCCUS SERA : I. THE MOUSE PROTECTIVE VALUE OF TYPE I SERA WITH REFERENCE TO THE PRECIPITIN CONTENT.

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