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PMID: 19870253 Published · ppublish English Journal Article

THE FILTERING CAPACITY OF LYMPH NODES.

The Journal of experimental medicine ·Vol. 59 ·No. 4 ·1934-03-31 ·Pages 393-405

Drinker CK, Field ME, Ward HK

Abstract

In anesthetized dogs the popliteal lymph node alone, and the popliteal and iliac lymph nodes in series, have been perfused with solutions containing dog erythrocytes and streptococci. The perfusions have been carried out under conditions of lymph flow and pressure within the limits of those occurring in the actively moving dog, or after a severe degree of inflammatory swelling has developed. Figures for filtration are given, with protocols of typical experiments. They indicate that normal lymph nodes possess a high degree of filtering efficiency-an efficiency so great as to make it fairly certain that in a part kept at rest early in an infection, practically no microorganisms would escape the nodes in the line of drainage.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Drinker C K
Department of Physiology, The Harvard School of Public Health, and the Department of Bacteriology, The Harvard Medical School, Boston.
Field M E
Ward H K
References (2)
2 references, click to expand
  1. THE PROTEINS OF BLOOD AND SUBCUTANEOUS LYMPH IN DOGS.
    J Clin Invest. 1933 Nov;12(6):1021-30 PMID: 16694177
  2. LYMPH PRESSURES IN STERILE INFLAMMATION.
    J Exp Med. 1932 Aug 31;56(3):363-70 PMID: 19870071
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
Published
1934-03-31
Pages
393-405
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2132334
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