THE TOXIC PROPERTIES OF SERUM EXTRACTS OF HEMOLYTIC STREPTOCOCCI.

The Journal of experimental medicine ·Vol. 59 ·No. 1 ·1934-01-01 ·Pages 83-95

Weld JT

Abstract

1. A method is described whereby toxic substances may be extracted from hemolytic streptococci with inactivated serum. 2. Such extracts contain large amounts of hemotoxin and leucocidin. 3. Their intravenous injection into mice causes marked hemoglobinuria, anemia, and death. 4. There is evidence that this anemia is not the only cause of death of these animals. 5. Incomplete work seems to indicate that the hemotoxin and the lethal poisons are not antigenic. 6. Certain biological properties of the extract are described.

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Weld J T

Department of Pathology, College of Physicians and Surgeons, Columbia University, New York.

References (5)

5 references, click to expand

DIFFERENTIATION BETWEEN CERTAIN TOXIC PROPERTIES OF FILTRATES OF HEMOLYTIC STAPHYLOCOCCUS AUREUS.
J Exp Med. 1931 Jul 31;54(3):315-22 PMID: 19869919
STUDIES ON OXIDATION AND REDUCTION BY PNEUMOCOCCUS : IV. OXIDATION OF HEMOTOXIN IN STERILE EXTRACTS OF PNEUMOCOCCUS.
J Exp Med. 1924 Apr 30;39(5):745-55 PMID: 19868881
ANTIGENIC STREPTOCOCCAL HEMOLYSIN.
J Exp Med. 1932 Jan 31;55(2):267-80 PMID: 19869990
STUDIES ON THE OXIDATION AND REDUCTION OF IMMUNOLOGICAL SUBSTANCES : IV. STREPTOLYSIN.
J Exp Med. 1926 Jul 31;44(2):241-60 PMID: 19869183
THE CONVERSION OF HEMOLYTIC STREPTOCOCCI TO NON-HEMOLYTIC FORMS.
J Exp Med. 1928 Sep 30;48(4):493-511 PMID: 19869500

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.59.1.83

Published

1934-01-01

Pages

83-95

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2132339

External Links

PubMed source DOI: 10.1084/jem.59.1.83 PMC Full Text View journal details

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