THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE.

The Journal of experimental medicine ·Vol. 114 ·No. 5 ·1961-10-31 ·Pages 825-32

Morgan C, Hsu KC, Rifkind RA, Knox AW, Rose HM

Abstract

Immersion of chorioallantoic membranes infected by influenza virus in ferritin-conjugated antibody globulin prior to fixation permits recognition of viral antigen at the cellular surface. In some cases the antigen is confined to sites at which viral particles appear to be in process of release, whereas in others it is present along the entire cellular surface. During infection part or all of the cellular membrane presumably is transformed so that it contains the antigenic and structural components which coat the virus during emergence. It is suggested that detached fragments of cytoplasm possessing surface hemagglutinin but incapable of initiating infection constitute at least one form of "incomplete virus."

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Morgan C

Department of Microbiology, College of Physicians and Surgeons, Columbia University, New York.

Hsu K C

Rifkind R A

Knox A W

Rose H M

References (13)

13 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.114.5.825

Published

1961-10-31

Pages

825-32

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2180370

External Links

PubMed source DOI: 10.1084/jem.114.5.825 PMC Full Text View journal details

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THE APPLICATION OF FERRITIN-CONJUGATED ANTIBODY TO ELECTRON MICROSCOPIC STUDIES OF INFLUENZA VIRUS IN INFECTED CELLS : I. THE CELLULAR SURFACE.

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