THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. ACUTE GLOMERULONEPHRITIS IN RATS.

The Journal of experimental medicine ·Vol. 111 ·No. 2 ·1960-01-31 ·Pages 195-200

Benacerraf B, Potter JL, McCluskey RT, Miller F

Abstract

The intravenous administration to rats of soluble antigen-antibody complexes in antigen excess resulted in acute glomerulonephritis. This occurred with both rabbit antiovalbumin and rabbit anti-BSA systems. The rats so treated regularly showed proteinuria and elevation of blood urea nitrogen. These findings are compared with those reported in rats injected with anti-kidney serum.

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Benacerraf B

Department of Pathology, New York University-Bellevue Medical Center, New York.

Potter J L

McCluskey R T

Miller F

References (3)

3 references, click to expand

Immediate or delayed nephritis in rats produced by duck anti-rat-kidney sera.
AMA Arch Pathol. 1957 Aug;64(2):192-204 PMID: 13443613
Localization of colloidal substances in vascular endothelium, a mechanism of tissue damage. II. Experimental serum sickness with acute glomerulonephritis induced passively in mice by antigen-antibody complexes in antigen excess.
Am J Pathol. 1959 Mar-Apr;35(2):275-95 PMID: 13627127
The pathologic effects of intravenously administered soluble antigen-antibody complexes. I. Passive serum sickness in mice.
J Exp Med. 1960 Feb 1;111:181-94 PMID: 13773804

Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.111.2.195

Published

1960-01-31

Pages

195-200

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2137255

External Links

PubMed source DOI: 10.1084/jem.111.2.195 PMC Full Text View journal details

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THE PATHOLOGIC EFFECTS OF INTRAVENOUSLY ADMINISTERED SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. ACUTE GLOMERULONEPHRITIS IN RATS.

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