On the relationship of liver glucose-6-phosphatase to the proliferation of endoplasmic reticulum in phenobarbital induction.

The Journal of cell biology ·Vol. 31 ·No. 2 ·1966-11-01 ·Pages 243-56

Orrenius S, Ericsson JL

Abstract

The differentiated effects of phenobarbital treatment on liver microsomal enzymes have been further studied. The relationship between the resulting decrease in the specific glucose-6-phosphatase activity and the enhancement of formation of endoplasmic reticulum membranes with high drug-hydroxylating activity has been investigated with biochemical and histochemical methods. Biochemically and histochemically demonstrable glucose-6-phosphatase activity was found to be present in all endoplasmic reticulum membranes, including the phenobarbital-induced smooth-surfaced proliferates, even though there was an over-all decrease in activity. Actinomycin D did not inhibit the decrease in glucose-6-phosphatase activity. The findings are discussed with reference to the enzyme-membrane relationship in phenobarbital induction.

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Orrenius S

Department of Pathology at Sabbatsberg Hospital, the Department of Forensic Pathology Karolinska Institutet, and The Wenner-Gren Institute, University of Stockholm, Stockholm, Sweden.

Ericsson J L

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Article Info

Journal

The Journal of cell biology

Abbr.

J Cell Biol

ISSN

0021-9525

DOI

10.1083/jcb.31.2.243

Published

1966-11-01

Pages

243-56

Language

English

Region

United States

NLM ID

0375356

PMCID

PMC2107056

External Links

PubMed source DOI: 10.1083/jcb.31.2.243 PMC Full Text View journal details

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On the relationship of liver glucose-6-phosphatase to the proliferation of endoplasmic reticulum in phenobarbital induction.

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