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题目:: Cancer genetics and reproduction.
作者:: Hanson(Helen),Hodgson(Shirley)
状态:: 发布时间2010-02-22 , 更新时间 2016-11-25
期刊:: Best Pract Res Clin Obstet Gynaecol
摘要:: Cancers of the reproductive organs (i.e., ovaries, uterus and testes), like other cancers, occur as a result of a multi-stage interaction of genetic and environmental factors. A small proportion of cancers of the reproductive organs occur as part of a recognised cancer syndrome, as a result of inheritance of mutations in highly penetrant cancer susceptibility genes (e.g., BRCA1, BRCA2, MLH1 or MSH2). Recognition of individuals and families with inherited cancer predisposition syndromes and individuals at high risk due to familial cancer clustering is fundamentally important for the management and treatment of the current cancer and for future prevention of further cancers for the individual and their extended family.
语言:: eng
DOI:: 10.1016/j.bpobgyn.2009.08.002

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