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题目:: Morphologic heterogeneity of human thymic nonlymphocytic cells.
作者:: Varga(Ivan),Mikusova(Renata),Pospisilova(Viera),Galfiova(Paulina),Adamkov(Marian),Polak(Stefan),Galbavy(Stefan)
状态:: 发布时间2009-11-25 , 更新时间 2009-11-25
期刊:: Neuro Endocrinol Lett
摘要:: The thymus is the central organ of the immune system. It is essential for the development and maintenance of normal immune system, especially cell-mediated immunity. From the morphological point of view, the thymus is divided into two main compartments, cortex and medulla. The thymic microenvironment consists of a network of reticular epithelial cells and other fixed and free cells. The microenvironment of thymus is very important for the selection and maturation of T cells. T cell differentiation occurs via T cell receptors. The major histocompatibility complex participates in interactions between T cells and thymic epithelial cells, in addition to interactions between T cells and dendritic cells, macrophages and myoid cells. The neuroendocrine system regulates early T cell differentiation by the transcription of neuroendocrine genes in the stromal network and expression of cognitive receptors by immature T cells. This work briefly summarizes morphological and ultrastructural characteristics of thymic epithelial cells, dendritic cells, macrophages and myoid cells. It is accompanied by the authors' own photomicrographs and electronmicrograph from a transmission electron microscope. All of these cells play a critical role in the proliferation, differentiation and selection of precursor cells in the T-cell lineage, but the precise mechanisms not well understudood.
语言:: eng
DOI:

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