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PMID: 19833543 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Non-genetic cell-to-cell variability and the consequences for pharmacology.

Current opinion in chemical biology ·Vol. 13 ·No. 5-6 ·2009-12-00 ·Pages 556-61

Niepel M, Spencer SL, Sorger PK

Abstract

Recent advances in single-cell assays have focused attention on the fact that even members of a genetically identical group of cells or organisms in identical environments can exhibit variability in drug sensitivity, cellular response, and phenotype. Underlying much of this variability is stochasticity in gene expression, which can produce unique proteomes even in genetically identical cells. Here we discuss the consequences of non-genetic cell-to-cell variability in the cellular response to drugs and its potential impact for the treatment of human disease.

MeSH Terms
Animals Cells/drug effects,metabolism,pathology Drug Therapy Humans Organ Specificity Pharmacological Phenomena Phenotype Proteins/metabolism
Chemicals
Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Niepel Mario
Center for Cell Decision Processes, Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Spencer Sabrina L
Sorger Peter K
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Article Info
Journal
Current opinion in chemical biology
Abbr.
Curr Opin Chem Biol
ISSN
1879-0402
DOI
10.1016/j.cbpa.2009.09.015
Published
2009-12-00
Epub
2009-00-14
Pages
556-61
Language
English
Region
England
NLM ID
9811312
PMCID
PMC2975492
Subset
IM
Grants
NIGMS NIH HHS · P50 GM068762-07 · United States
NCI NIH HHS · CA112967 · United States
NIGMS NIH HHS · P50 GM068762 · United States
NCI NIH HHS · U54 CA112967-06 · United States
NIGMS NIH HHS · GM68762 · United States
NCI NIH HHS · U54 CA112967 · United States
External Links
PubMed source DOI: 10.1016/j.cbpa.2009.09.015 PMC Full Text View journal details
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