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PMID: 19832839 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Recent insights into PDGF-induced gliomagenesis.

Brain pathology (Zurich, Switzerland) ·Vol. 20 ·No. 3 ·2010-05-00 ·Pages 527-38

Calzolari F, Malatesta P

Abstract

Gliomas are aggressive and almost incurable glial brain tumors which frequently display abnormal platelet-derived growth factor (PDGF) signaling. Evidence gained from studies on several in vivo animal models has firmly established a causal connection between aberrant PDGF signaling and the formation of some gliomas. However, only recently has significant knowledge been gained regarding crucial issues such as the glioma cell of origin and the relationship between the transforming stimulus and the cellular characteristics of the resulting tumor. Based on recent evidence, we propose that PDGF can bias cell-fate decisions, driving the acquisition of cell type-specific features by the progeny of multipotent neural progenitors, thus determining the shape and direction of the transformation path. Furthermore, recent data about the cellular mechanisms of PDGF-driven glioma progression and maintenance indicate that PDGF may be required, unexpectedly, to override cell contact inhibition and promote glioma cell infiltration rather than to stimulate cell proliferation.

MeSH Terms
Animals Brain Neoplasms/genetics,metabolism,pathology Cell Transformation, Neoplastic/genetics,metabolism,pathology Glioma/genetics,metabolism,pathology Humans Platelet-Derived Growth Factor/genetics,physiology
Chemicals
Platelet-Derived Growth Factor
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Calzolari Filippo
National Institute for Cancer Research (IST), IRCCS, and Department of Oncology Biology and Genetics (DOBIG), University of Genoa, Genoa, Italy.
Malatesta Paolo
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Article Info
Journal
Brain pathology (Zurich, Switzerland)
Abbr.
Brain Pathol
ISSN
1750-3639
DOI
10.1111/j.1750-3639.2009.00335.x
Published
2010-05-00
Epub
2009-00-25
Pages
527-38
Language
English
Region
Switzerland
NLM ID
9216781
PMCID
PMC8094702
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1750-3639.2009.00335.x PMC Full Text View journal details
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