Cardiac metabolic state and Brugada syndrome: a link revealed.

Animals Antineoplastic Agents/pharmacology Benzophenanthridines/pharmacology Brugada Syndrome/genetics,metabolism Cell Line Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors,genetics,metabolism Down-Regulation/drug effects,genetics Enzyme Inhibitors/pharmacology Glycerolphosphate Dehydrogenase/genetics,metabolism Humans Mice Muscle Proteins/genetics,metabolism Mutation Myocardium/metabolism NAD/genetics,metabolism NAV1.5 Voltage-Gated Sodium Channel Oxidation-Reduction Protein Kinase C/antagonists & inhibitors,genetics,metabolism Rats Sodium/metabolism Sodium Channels/genetics,metabolism Superoxide Dismutase/genetics,metabolism Tachycardia, Ventricular/genetics,metabolism

Antineoplastic Agents Benzophenanthridines Enzyme Inhibitors Muscle Proteins NAV1.5 Voltage-Gated Sodium Channel SCN5A protein, human Scn5a protein, mouse Scn5a protein, rat Sodium Channels NAD Sodium chelerythrine GPD1L protein, human Glycerolphosphate Dehydrogenase Superoxide Dismutase Cyclic AMP-Dependent Protein Kinases Protein Kinase C