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PMID: 1981563 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

NMDA receptor antagonists reduce medial, but not lateral, perforant path-evoked EPSPs in dentate gyrus of rat hippocampal slice.

Experimental brain research ·Vol. 83 ·No. 1 ·1990-00-00 ·Pages 172-7

Dahl D, Burgard EC, Sarvey JM

Abstract

NMDA receptor antagonists produced differential effects on medial and lateral perforant path-evoked excitatory postsynaptic potentials (EPSPs) recorded in the dentate gyrus molecular layer of hippocampal slices. D-(-)-2-amino-5-phosphonovaleric acid (D(-)-APV) and 3[(+/-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) significantly reduced the peak amplitude and total area, but not the initial negative slope, of the medial perforant path-evoked EPSP. Neither antagonist affected any component of the lateral perforant path-evoked EPSP. In contrast, population spikes evoked by stimulation of either pathway were depressed.

MeSH Terms
2-Amino-5-phosphonovalerate/pharmacology Animals Hippocampus/physiology Male Membrane Potentials/drug effects,physiology Neuromuscular Junction/drug effects,physiology Organophosphorus Compounds/pharmacology Piperazines/pharmacology Rats Rats, Inbred Strains Receptors, N-Methyl-D-Aspartate/physiology Synapses/drug effects,physiology
Chemicals
Organophosphorus Compounds Piperazines Receptors, N-Methyl-D-Aspartate SDZ EAA 494 2-Amino-5-phosphonovalerate
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dahl D
Department of Pharmacology, Uniformed Services University of the Health Sciences, Bethesda, MD 20889-4799.
Burgard E C
Sarvey J M
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Article Info
Journal
Experimental brain research
Abbr.
Exp Brain Res
ISSN
0014-4819
DOI
10.1007/BF00232206
Published
1990-00-00
Pages
172-7
Language
English
Region
Germany
NLM ID
0043312
Subset
IM
Grants
NINDS NIH HHS · NS 23865 · United States
External Links
PubMed source DOI: 10.1007/BF00232206 View journal details
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