Abstract
Our aim was to determine the incidence of anatomical abnormalities after a urinary tract infection (UTI) in infants <2 months of age hospitalized in the neonatal intensive care unit (NICU). This was a retrospective, single-center cohort study of infants <2 months of age in the NICU with a UTI and documented renal imaging. We identified 141 infants with UTIs. The mean gestational age and birth weight were 28 weeks and 1254 g, respectively. The most commonly identified pathogen was coagulase-negative Staphylococcus (28%, 44 of 156). A major abnormality was found on at least one imaging study for 4% (5 of 118) of infants. Major abnormalities were noted on 4% (5 of 114) of renal ultrasounds and 2% (2 of 82) of voiding cystourethrography examinations. Among infants in the NICU <2 months of age at the time of a UTI, the prevalence of major anatomical abnormalities is <5%.
MeSH Terms
Academic Medical Centers/statistics & numerical data
Female
Humans
Hydronephrosis/complications,diagnostic imaging,epidemiology
Infant
Infant, Newborn
Intensive Care Units, Neonatal/statistics & numerical data
Male
North Carolina/epidemiology
Prevalence
Ultrasonography
Urinary Tract Infections/complications
Urogenital Abnormalities/complications,diagnostic imaging,epidemiology
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Nowell L
Duke University School of Medicine, Durham, NC, USA.
Moran C
Smith P B
Seed P
Alexander B D
Cotten C M
Wiener J S
Benjamin D K
References (23)
23 references, click to expand
-
Fluoroscopy-controlled voiding cystourethrography in infants and children: are the radiation risks trivial?
Eur Radiol. 2006 Apr;16(4):846-51
PMID: 16328446
-
Clinical and demographic factors associated with urinary tract infection in young febrile infants.
Pediatrics. 2005 Sep;116(3):644-8
PMID: 16140703
-
First urinary tract infection in neonates, infants and young children: a comparative study.
Pediatr Nephrol. 2006 Aug;21(8):1131-7
PMID: 16810514
-
Urinary tract infection in febrile infants younger than eight weeks of Age.
Pediatrics. 2000 Feb;105(2):E20
PMID: 10654980
-
Voiding cystourethrography: the initial radiologic study in children with urinary tract infection.
Radiology. 1985 Sep;156(3):659-62
PMID: 4040642
-
Urinary tract infections in young febrile children.
Pediatr Infect Dis J. 1997 Jan;16(1):11-7
PMID: 9002094
-
Routine diagnostic imaging for childhood urinary tract infections: a systematic overview.
J Pediatr. 1996 Jan;128(1):15-22
PMID: 8551409
-
Acute renal damage in infants after first urinary tract infection.
Pediatr Nephrol. 2002 Jul;17(7):503-5
PMID: 12172762
-
Urinary tract infections in young infants.
Pediatrics. 1982 Apr;69(4):409-12
PMID: 7070887
-
Urinary tract infection in very low birth weight preterm infants.
Pediatr Infect Dis J. 2003 May;22(5):426-30
PMID: 12792383
-
Urinary tract infection: is there a need for routine renal ultrasonography?
Arch Dis Child. 2004 May;89(5):466-8
PMID: 15102643
-
Ultrasound grading of hydronephrosis: introduction to the system used by the Society for Fetal Urology.
Pediatr Radiol. 1993;23(6):478-80
PMID: 8255658
-
Cohort study of bacterial species causing urinary tract infection and urinary tract abnormalities in children.
BMJ. 1999 Mar 20;318(7186):770-1
PMID: 10082700
-
Prevalence of vesicoureteral reflux in neonatal urinary tract infection.
Clin Pediatr (Phila). 2004 Sep;43(7):619-25
PMID: 15378148
-
Practice parameter: the diagnosis, treatment, and evaluation of the initial urinary tract infection in febrile infants and young children. American Academy of Pediatrics. Committee on Quality Improvement. Subcommittee on Urinary Tract Infection.
Pediatrics. 1999 Apr;103(4 Pt 1):843-52
PMID: 10103321
-
Clinical significance of primary vesicoureteral reflux and urinary antibiotic prophylaxis after acute pyelonephritis: a multicenter, randomized, controlled study.
Pediatrics. 2006 Mar;117(3):626-32
PMID: 16510640
-
Imaging after urinary tract infection in male neonates.
Pediatrics. 2000 Jun;105(6):1232-5
PMID: 10835062
-
Diagnostic workup of urinary tract infections within the first 24 months of life, in the era of prenatal diagnosis. The contribution of different imaging techniques to clinical management.
Minerva Pediatr. 2005 Oct;57(5):269-73
PMID: 16205610
-
Jaundice as an early diagnostic sign of urinary tract infection in infancy.
Pediatrics. 2002 May;109(5):846-51
PMID: 11986445
-
International system of radiographic grading of vesicoureteric reflux. International Reflux Study in Children.
Pediatr Radiol. 1985;15(2):105-9
PMID: 3975102
-
Urinary tract infections in febrile infants younger than 8 weeks of age.
Pediatrics. 1990 Sep;86(3):363-7
PMID: 2388785
-
Vesicoureteral reflux, a benign condition.
Pediatr Nephrol. 2009 Feb;24(2):223-6
PMID: 18604562
-
Renal ultrasound findings and vesicoureteral reflux in children hospitalised with urinary tract infection.
Arch Dis Child. 2002 Jun;86(6):419-20
PMID: 12023172