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PMID: 19775929 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Glycomics and disease markers.

Current opinion in chemical biology ·Vol. 13 ·No. 5-6 ·2009-12-00 ·Pages 601-7

An HJ, Kronewitter SR, de Leoz ML, Lebrilla CB

Abstract

Glycomics is the comprehensive study of all glycans expressed in biological systems. The biosynthesis of glycan relies on a number of highly competitive processes involving glycosyl transferases. Glycosylation is therefore highly sensitive to the biochemical environment and has been implicated in many diseases including cancer. Recently, interest in profiling the glycome has increased owing to the potential of glycans for disease markers. In this regard, mass spectrometry is emerging as a powerful technique for profiling the glycome. Global glycan profiling of human serum based on mass spectrometry has already led to several potentially promising markers for several types of cancer and diseases.

MeSH Terms
Animals Biomarkers/metabolism Disease Glycomics/methods Glycosylation Humans Mass Spectrometry Polysaccharides/metabolism
Chemicals
Biomarkers Polysaccharides
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
An Hyun Joo
Department of Chemistry, University of California, Davis, CA 95616, United States.
Kronewitter Scott R
de Leoz Maria Lorna A
Lebrilla Carlito B
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Article Info
Journal
Current opinion in chemical biology
Abbr.
Curr Opin Chem Biol
ISSN
1879-0402
DOI
10.1016/j.cbpa.2009.08.015
Published
2009-12-00
Epub
2009-00-21
Pages
601-7
Language
English
Region
England
NLM ID
9811312
PMCID
PMC2788081
Subset
IM
Grants
NIGMS NIH HHS · R01 GM049077-14 · United States
NIGMS NIH HHS · R01 GM049077-16S1 · United States
NICHD NIH HHS · R01 HD061923 · United States
NIGMS NIH HHS · R01 GM049077 · United States
NIGMS NIH HHS · R01GM049077 · United States
NIGMS NIH HHS · R01 GM049077-15 · United States
NICHD NIH HHS · R01 HD061923-01 · United States
NIGMS NIH HHS · R01 GM049077-16 · United States
External Links
PubMed source DOI: 10.1016/j.cbpa.2009.08.015 PMC Full Text View journal details
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