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PMID: 19759556 Published · ppublish English Letter Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

TP53 mutations in myeloid malignancies are either homozygous or hemizygous due to copy number-neutral loss of heterozygosity or deletion of 17p.

Leukemia ·Vol. 24 ·No. 1 ·2010-01-00 ·Pages 216-9

Jasek M, Gondek LP, Bejanyan N, Tiu R, Huh J, Theil KS, O'Keefe C, McDevitt MA, Maciejewski JP

Abstract

暂无摘要

MeSH Terms
Chromosome Deletion Chromosomes, Human, Pair 17 Gene Dosage Genes, p53 Humans Leukemia, Myeloid, Acute/genetics Loss of Heterozygosity Mutation Myelodysplastic Syndromes/genetics
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Jasek M
Gondek L P
Bejanyan N
Tiu R
Huh J
Theil K S
O'Keefe C
McDevitt M A
Maciejewski J P
References (8)
8 references, click to expand
  1. Loss of heterozygosity or intragenic mutation, which comes first?
    Am J Pathol. 2001 May;158(5):1561-3 PMID: 11337351
  2. Gains, losses and complex karyotypes in myeloid disorders: a light at the end of the tunnel.
    Hematol Oncol. 2005 Mar;23(1):18-25 PMID: 16142824
  3. Whole genome scanning as a cytogenetic tool in hematologic malignancies.
    Blood. 2008 Aug 15;112(4):965-74 PMID: 18505780
  4. Mutations of the TP53 gene in acute myeloid leukemia are strongly associated with a complex aberrant karyotype.
    Leukemia. 2008 Aug;22(8):1539-41 PMID: 18528419
  5. Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database.
    Hum Mutat. 2007 Jun;28(6):622-9 PMID: 17311302
  6. Mutations with loss of heterozygosity of p53 are common in therapy-related myelodysplasia and acute myeloid leukemia after exposure to alkylating agents and significantly associated with deletion or loss of 5q, a complex karyotype, and a poor prognosis.
    J Clin Oncol. 2001 Mar 1;19(5):1405-13 PMID: 11230485
  7. TP53 gene mutation is frequent in patients with acute myeloid leukemia and complex karyotype, and is associated with very poor prognosis.
    Leukemia. 2009 Jan;23(1):203-6 PMID: 18596741
  8. Myelodysplastic syndromes and acute myeloid leukemia with 17p deletion. An entity characterized by specific dysgranulopoïesis and a high incidence of P53 mutations.
    Leukemia. 1995 Mar;9(3):370-81 PMID: 7885035
Article Info
Journal
Leukemia
Abbr.
Leukemia
ISSN
1476-5551
DOI
10.1038/leu.2009.189
Published
2010-01-00
Epub
2009-00-17
Pages
216-9
Language
English
Region
England
NLM ID
8704895
PMCID
PMC2806506
Subset
IM
Grants
NHLBI NIH HHS · R01 HL082983-04 · United States
NHLBI NIH HHS · K24 HL077522 · United States
NCRR NIH HHS · U54 RR019391 · United States
NCRR NIH HHS · U54 RR019397 · United States
NHLBI NIH HHS · K24 HL-077522 · United States
NHLBI NIH HHS · R01HL-082983 · United States
NCRR NIH HHS · U54 RR019397-05S1 · United States
NHLBI NIH HHS · R01 HL082983 · United States
NHLBI NIH HHS · K24 HL077522-05 · United States
External Links
PubMed source DOI: 10.1038/leu.2009.189 PMC Full Text View journal details
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