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PMID: 19756448 Published · ppublish English Journal Article Review

A novel mechanism for inflammation-associated carcinogenesis; an important role of activation-induced cytidine deaminase (AID) in mutation induction.

Journal of molecular medicine (Berlin, Germany) ·Vol. 87 ·No. 10 ·2009-10-00 ·Pages 1023-7

Chiba T, Marusawa H

Abstract

Inflammation is a risk for cancer development; however, its mechanism is unknown. Recent studies have revealed that activation-induced cytidine deaminase (AID), which plays essential roles in both class-switch recombination and somatic hypermutation of immunoglobulin gene in B lymphocytes, is aberrantly expressed in non-lymphoid cells not only by H.pylori and HCV infection but also by various proinflammatory cytokines, leading to the generation of gene mutations. These findings not only suggested a new mechanism of inflammation-associated carcinogenesis but has also opened up a new field of tumor biology.

MeSH Terms
Animals B-Lymphocytes/enzymology,immunology,physiology Cytidine Deaminase/immunology Genomic Instability Helicobacter Infections/immunology Hepatitis C/immunology Humans Inflammation/immunology Liver/enzymology,virology Liver Neoplasms/enzymology,virology Mutation NF-kappa B/metabolism Neoplasms/etiology,genetics,immunology Stomach Neoplasms/enzymology,microbiology Viral Core Proteins/metabolism
Chemicals
NF-kappa B Viral Core Proteins AICDA (activation-induced cytidine deaminase) Cytidine Deaminase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chiba Tsutomu
Department of Gastroenterology and Hepatology, Graduate School of Medicine, Kyoto University, Sakyo, Kyoto, Japan. chiba@kuhp.kyoto-u.ac.jp
Marusawa Hiroyuki
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Article Info
Journal
Journal of molecular medicine (Berlin, Germany)
Abbr.
J Mol Med (Berl)
ISSN
1432-1440
DOI
10.1007/s00109-009-0527-3
Email
chiba@kuhp.kyoto-u.ac.jp
Published
2009-10-00
Pages
1023-7
Language
English
Region
Germany
NLM ID
9504370
Subset
IM
External Links
PubMed source DOI: 10.1007/s00109-009-0527-3 View journal details
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