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PMID: 197531 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 74 ·No. 7 ·1977-07-00 ·Pages 3065-7

Staal SP, Hartley JW, Rowe WP

Abstract

Murine leukemia viruses capable of malignant transformation of mink tissue culture cells have been isolated from an AKR thymoma cell line and from a spontaneous reticulum cell sarcoma in an NIH Swiss mouse partially congenic for the AKR ecotropic virus-inducing locus Akv-2. In contrast to the recently described mink cell focus-inducing strains of murine leukemia virus, at least one of the two transforming strains is replication defective. Nonproducer mink cells carrying the genome of the transforming virus of AKR origin have been isolated, and pseudotype transforming viruses generated.

MeSH Terms

Animals Cell Line Cell Transformation, Neoplastic Defective Viruses/isolation & purification Leukemia Virus, Murine/isolation & purification Lymphoma, Large B-Cell, Diffuse/microbiology Mice Mice, Inbred AKR/microbiology Mink Species Specificity Thymoma/microbiology Virus Replication

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Staal S P

Hartley J W

Rowe W P

References (12)

12 references, click to expand

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Proc Natl Acad Sci U S A. 1975 Nov;72(11):4435-9 PMID: 172908
Changes in expression of murine leukemia virus antigens and production of xenotropic virus in the late preleukemic period in AKR mice.
Proc Natl Acad Sci U S A. 1976 Dec;73(12):4680-4 PMID: 188051
Rates of aggregation, loss of anchorage dependence, and tumorigenicity of cultured cells.
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A new class of murine leukemia virus associated with development of spontaneous lymphomas.
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Friend strain of spleen focus-forming virus: a recombinant between mouse type C ecotropic viral sequences and sequences related to xenotropic virus.
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Virology. 1974 Jul;60(1):282-7 PMID: 4366800
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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.74.7.3065

Published

1977-07-00

Pages

3065-7

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC431413

Subset

External Links

PubMed source DOI: 10.1073/pnas.74.7.3065 PMC Full Text View journal details

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Isolation of transforming murine leukemia viruses from mice with a high incidence of spontaneous lymphoma.

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