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PMID: 1974368 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

How the messenger got its tail: addition of poly(A) in the nucleus.

Trends in biochemical sciences ·Vol. 15 ·No. 7 ·1990-07-00 ·Pages 277-81

Wickens M

Abstract

Most mRNAs end in a poly(A) tail, the addition of which is catalysed by a poly(A) polymerase in conjunction with a distinct factor that provides specificity for mRNAs. The reaction is dynamic, involving separable initiation, elongation and termination phases. A companion article in next month's TIBS will review the regulation of poly(A) addition and removal during early animal development.

MeSH Terms

Animals Base Sequence Biological Factors/metabolism Cell Nucleus/metabolism Humans Molecular Sequence Data Poly A/biosynthesis,metabolism Polynucleotide Adenylyltransferase/metabolism RNA, Messenger/biosynthesis,metabolism

Chemicals

Biological Factors RNA, Messenger Poly A Polynucleotide Adenylyltransferase

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Wickens M

Department of Biochemistry, Graduate School, College of Agriculture and Life Sciences, University of Wisconsin-Madison 53796.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

DOI

10.1016/0968-0004(90)90054-f

Published

1990-07-00

Pages

277-81

Language

English

Region

England

NLM ID

7610674

Subset

Grants

NIGMS NIH HHS · GM00521 · United States

NIGMS NIH HHS · GM31892 · United States

External Links

PubMed source DOI: 10.1016/0968-0004(90)90054-f View journal details

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How the messenger got its tail: addition of poly(A) in the nucleus.

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