Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase.

Naunyn-Schmiedeberg's archives of pharmacology ·Vol. 298 ·No. 3 ·1977-07-00 ·Pages 255-7

Fitzpatrick DF, Szentivanyi A

Abstract

Enhancement of calcium uptake into rabbit aortic microsomes was seen at a cyclic AMP concentration of 10(-6) M in the presence of cyclic AMP-dependent protein kinase (ATP: protein phosphotransferase, EC 2.7.1.37). Protein kinase alone also increased calcium uptake, but cyclic AMP alone was without effect. The results suggest that stimulation of calcium sequestration may be the mechanism of cyclic AMP involvement in vascular smooth muscle relaxation.

MeSH Terms

Animals Aorta/metabolism,ultrastructure Calcium/metabolism Cyclic AMP/pharmacology In Vitro Techniques Microsomes/drug effects,metabolism Muscle, Smooth/metabolism,ultrastructure Myocardium/ultrastructure Protein Kinases/pharmacology Rabbits Stimulation, Chemical Time Factors

Chemicals

Cyclic AMP Protein Kinases Calcium

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Fitzpatrick D F

Szentivanyi A

References (9)

9 references, click to expand

Localization of calcium pump activity in smooth muscle.
Science. 1973 Jan 26;179(4071):384-6 PMID: 4405060
Effects of angiotensin, catecholamines and cyclic AMP on calcium storage in aortic microsomes.
Br J Pharmacol. 1973 Feb;47(2):377-85 PMID: 4352869
A calcium pump in vascular smooth muscle.
Science. 1972 Apr 21;176(4032):305-6 PMID: 5019786
Adenosine 3':5'-monophosphate-dependent protein kinase-catalyzed phosphorylation reaction and its relationship to calcium transport in cardiac sarcoplasmic reticulum.
J Biol Chem. 1974 Oct 10;249(19):6166-73 PMID: 4371435
The stimulation of calcium transport in cardiac sarcoplasmic reticulum by adenosine 3':5'-monophosphate-dependent protein kinase.
J Biol Chem. 1974 Oct 10;249(19):6174-80 PMID: 4371608
Role of cyclic AMP and Ca++ in metabolic and mechanical events in smooth muscle.
Adv Cyclic Nucleotide Res. 1972;1:213-29 PMID: 4353169
Rate of calcium binding and uptake in normal animal and failing human cardiac muscle. Membrane vesicles (relaxing system) and mitochondria.
Circ Res. 1969 Dec;25(6):781-94 PMID: 5364651
Characterization of dog cardiac microsomes. Use of zonal centrifugation to fractionate fragmented sarcoplasmic reticulum, (Na+ + K+)--activated ATPase and mitochondrial fragments.
Biochim Biophys Acta. 1970 Jun 30;205(3):473-90 PMID: 4249366
ATP-dependent Ca uptake by subcellular fractions of uterine smooth muscle.
Comp Biochem Physiol A Comp Physiol. 1971 Feb 1;38(2):369-85 PMID: 4397610

Article Info

Journal

Naunyn-Schmiedeberg's archives of pharmacology

Abbr.

Naunyn Schmiedebergs Arch Pharmacol

ISSN

0028-1298

DOI

10.1007/BF00500896

Published

1977-07-00

Pages

255-7

Language

English

Region

Germany

NLM ID

0326264

Subset

External Links

PubMed source DOI: 10.1007/BF00500896 View journal details

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Stimulation of calcium uptake into aortic microsomes by cyclic AMP and cyclic AMP-dependent protein kinase.

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