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PMID: 1974178 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Autoreactive cytotoxicity in HIV-infected individuals.

Clinical and experimental immunology ·Vol. 81 ·No. 1 ·1990-07-00 ·Pages 18-24

Israël-Biet D, Venet A, Beldjord K, Andrieu JM, Even P

Abstract

A possible role for autoimmunity in the pathogenesis of HIV infection has been suggested, based upon the certain degree of homology shared by HIV gp41 and MHC class II molecules. A number of humoral markers of autoimmunity have since been found in seropositive subjects. We have evaluated the cellular autoreactive response in HIV-infected individuals. Our study demonstrates the existence of a cytolytic activity, present in seropositive but not in seronegative subjects. This activity is mediated by CD3+ T cells, which only occasionally express the CD8 or the CD4 surface markers. Effector cells do not appear to exert their activity in a MHC-restricted fashion, since allogeneic target cells could also be killed, recovered from allogeneic seropositive as well as from seronegative subjects. Several types of target cells were lysed: T cell blasts and Epstein-Barr virus (EBV) transformed B cells, suggesting that the target antigen is common to at least these two cell types. The fact that cells from seronegative individuals were lysed argues against the recognition of an HIV-specific antigen. The nature of the target determinants and the identity of the effector cells are discussed.

MeSH Terms
Antigens, CD/analysis Antigens, Differentiation/analysis Antigens, Differentiation, T-Lymphocyte/analysis Autoimmunity CD3 Complex CD4-Positive T-Lymphocytes/immunology CD8 Antigens Cytotoxicity, Immunologic HIV Infections/immunology HIV Seropositivity/immunology Humans Immunity, Cellular Lymphopenia/immunology Receptors, Antigen, T-Cell/analysis Receptors, Fc/analysis Receptors, IgG T-Lymphocytes, Cytotoxic/immunology
Chemicals
Antigens, CD Antigens, Differentiation Antigens, Differentiation, T-Lymphocyte CD3 Complex CD8 Antigens Receptors, Antigen, T-Cell Receptors, Fc Receptors, IgG
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Israël-Biet D
Laënnec HIV Study Group, Hôpital Laennec, Paris, France.
Venet A
Beldjord K
Andrieu J M
Even P
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
DOI
10.1111/j.1365-2249.1990.tb05285.x
Published
1990-07-00
Pages
18-24
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1535018
Subset
IM
External Links
PubMed source DOI: 10.1111/j.1365-2249.1990.tb05285.x PMC Full Text View journal details
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