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题目:: Enhancement of mucus accumulation in a human gastric scirrhous carcinoma cell line (KATO-III) by fibroblast-tumor cell interaction.
作者:: Yamamoto(R),Iishi(H),Tatsuta(M),Nakamura(H),Terada(N),Komatsu(K),Matsusaka(T)
状态:: 发布时间1990-09-04 , 更新时间 2004-11-17
期刊:: Virchows Arch B Cell Pathol Incl Mol Pathol
摘要:: Human fibroblasts (WI-38 cells) were found to enhance mucus accumulation by human scirrhous carcinoma cells (KATO-III cells). Coculture of KATO-III with WI-38 cells resulted in enlargement of the KATO-III cells and increases in the proportions of PAS- and colloidal iron-positive KATO-III cells. These morphological alterations were reversed when the KATO-III cells were again cultured without WI-38 cells. Conditioned media from cultures of WI-38 cells or cocultures of KATO-III and WI-38 cells induced the same morphological alterations in KATO-III cells, suggesting that WI-38 cells produce a factor or factors that enhance mucus accumulation in KATO-III cells. This factor seemed to be a protein with a molecular weight of more than 10,000 daltons.
语言:: eng
DOI:

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