Home LiteratureArticle Details
PMID: 197272 Published · ppublish English Journal Article

Correlation of virus polypeptide structure with attenuation of poliovirus type 1.

Journal of virology ·Vol. 23 ·No. 3 ·1977-09-00 ·Pages 811-5

Milstien JB, Walker JR, Eron LJ

Abstract

Several avirulent samples of poliovirus type 1 derived in the process attenuating the neurovirulent Mahoney strain show an altered virus capsid polypeptide, VP-1, on polyacrylamide gel electrophoresis of sodium dodecyl sulfate-disrupted virions.

MeSH Terms
Capsid/analysis Peptides/analysis Poliovirus/analysis,growth & development,pathogenicity Poliovirus Vaccine, Inactivated Vaccines, Attenuated Viral Proteins/analysis Virulence Virus Cultivation
Chemicals
Peptides Poliovirus Vaccine, Inactivated Vaccines, Attenuated Viral Proteins
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Milstien J B
Walker J R
Eron L J
References (6)
6 references, click to expand
  1. Improved method for staining cell monolayers for virus plaque counts.
    J Bacteriol. 1959 Oct;78:596-7 PMID: 14402608
  2. Isolation of a non-neurotropic variant of type I poliomyelitis virus.
    Proc Soc Exp Biol Med. 1954 Oct;87(1):148-53 PMID: 13224709
  3. Three structural polypeptides coded for by minite virus of mice, a parvovirus.
    J Virol. 1976 Oct;20(1):273-89 PMID: 988192
  4. Polypeptide composition of poliovirions, naturally occurring empty capsids, and 14S precursor particles.
    J Virol. 1973 Aug;12(2):291-9 PMID: 4355933
  5. Cleavage site alterations in poliovirus-specific precursor proteins.
    Virology. 1976 Aug;73(1):216-27 PMID: 183354
  6. Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
    Nature. 1970 Aug 15;227(5259):680-5 PMID: 5432063
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.23.3.811-815.1977
Published
1977-09-00
Pages
811-5
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC515892
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.23.3.811-815.1977 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2