RISC hitches onto endosome trafficking.

Nature cell biology ·Vol. 11 ·No. 9 ·2009-09-00 ·Pages 1049-51

Siomi H, Siomi MC

Abstract

The RNA-induced silencing complex (RISC) downregulates expression of the genes targeted by RNA-silencing pathways. But formation and turnover of the RISC complex itself is tightly regulated and requires endosomal membranes.

MeSH Terms

Animals Drosophila Proteins/metabolism Drosophila melanogaster/cytology,metabolism Endosomes/metabolism,ultrastructure Humans MicroRNAs/metabolism Models, Biological Protein Transport RNA, Small Interfering/metabolism RNA-Induced Silencing Complex/metabolism

Chemicals

Drosophila Proteins MicroRNAs RNA, Small Interfering RNA-Induced Silencing Complex

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Siomi Haruhiko

Siomi Mikiko C

References (12)

12 references, click to expand

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers.
Nat Cell Biol. 2008 Dec;10(12):1470-6 PMID: 19011622
Multivesicular bodies associate with components of miRNA effector complexes and modulate miRNA activity.
Nat Cell Biol. 2009 Sep;11(9):1143-9 PMID: 19684575
Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway.
RNA. 2009 Jul;15(7):1282-91 PMID: 19451544
P bodies and the control of mRNA translation and degradation.
Mol Cell. 2007 Mar 9;25(5):635-46 PMID: 17349952
The biogenesis and functions of exosomes.
Traffic. 2002 May;3(5):321-30 PMID: 11967126
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Nat Cell Biol. 2007 Jun;9(6):654-9 PMID: 17486113
The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins.
Nature. 2009 Mar 26;458(7237):445-52 PMID: 19325624
P bodies: at the crossroads of post-transcriptional pathways.
Nat Rev Mol Cell Biol. 2007 Jan;8(1):9-22 PMID: 17183357
GERp95, a membrane-associated protein that belongs to a family of proteins involved in stem cell differentiation.
Mol Biol Cell. 1999 Oct;10(10):3357-72 PMID: 10512872
Silencing by small RNAs is linked to endosomal trafficking.
Nat Cell Biol. 2009 Sep;11(9):1150-6 PMID: 19684574
Murine Hermansky-Pudlak syndrome genes: regulators of lysosome-related organelles.
Bioessays. 2004 Jun;26(6):616-28 PMID: 15170859
On the road to reading the RNA-interference code.
Nature. 2009 Jan 22;457(7228):396-404 PMID: 19158785

Article Info

Journal

Nature cell biology

Abbr.

Nat Cell Biol

ISSN

1476-4679

DOI

10.1038/ncb0909-1049

Published

2009-09-00

Pages

1049-51

Language

English

Region

England

NLM ID

100890575

Subset

Corrections

CommentOn

PMID: 19684574

CommentOn

PMID: 19684575

External Links

PubMed source DOI: 10.1038/ncb0909-1049 View journal details

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RISC hitches onto endosome trafficking.

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