Hypothesis: does breast cancer originate in utero?

Lancet (London, England) ·Vol. 335 ·No. 8695 ·1990-04-21 ·Pages 939-40

Trichopoulos D

Abstract

Factors that increase the risk of cancer during adult life may also increase the risk of cancer when they act in utero (eg, ionising radiation and diethylstilboestrol in human beings and chemicals in animals). The existing empirical data seem to be compatible with the hypothesis that increased concentrations of oestrogens in pregnancy increase the probability of future occurrence of breast cancer in daughters.

MeSH Terms

Adult Breast Neoplasms/etiology Diet/adverse effects Diethylstilbestrol/adverse effects Estrogens/adverse effects,blood Female Humans Neoplasms, Radiation-Induced/etiology Pregnancy/blood Prenatal Exposure Delayed Effects Risk Factors

Chemicals

Estrogens Diethylstilbestrol

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Trichopoulos D

Department of Epidemiology, School of Public Health, Harvard University, Boston, Massachusetts 02115.

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/0140-6736(90)91000-z

Published

1990-04-21

Pages

939-40

Language

English

Region

England

NLM ID

2985213R

Subset

Corrections

CommentIn

PMID: 1972531

External Links

PubMed source DOI: 10.1016/0140-6736(90)91000-z View journal details

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Hypothesis: does breast cancer originate in utero?

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