LAT polices T cell activation.

Immunity ·Vol. 31 ·No. 2 ·2009-08-21 ·Pages 174-6

Brownlie R, Zamoyska R

Abstract

Mutations in the adaptor molecule LAT can lead to autoimmunity. In this issue of Immunity, Mingueneau et al. (2009) describe how this may not be a failure of central tolerance.

MeSH Terms

Adaptor Proteins, Signal Transducing/genetics,immunology,metabolism Animals Autoimmunity Lymphocyte Activation Membrane Proteins/genetics,immunology,metabolism Mice Mutation/genetics Phosphoproteins/genetics,immunology,metabolism Receptors, Antigen, T-Cell/immunology,metabolism Signal Transduction/immunology T-Lymphocyte Subsets/immunology,metabolism ZAP-70 Protein-Tyrosine Kinase/genetics,immunology,metabolism

Chemicals

Adaptor Proteins, Signal Transducing Lat protein, mouse Membrane Proteins Phosphoproteins Receptors, Antigen, T-Cell ZAP-70 Protein-Tyrosine Kinase Zap70 protein, mouse

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Brownlie Rebecca

Institute for Immunology and Infection Research, The University of Edinburgh, Edinburgh EH9 3JT, UK.

Zamoyska Rose

Article Info

Journal

Immunity

Abbr.

Immunity

ISSN

1097-4180

DOI

10.1016/j.immuni.2009.08.002

Published

2009-08-21

Pages

174-6

Language

English

Region

United States

NLM ID

9432918

Subset

Corrections

CommentOn

PMID: 19682930

External Links

PubMed source DOI: 10.1016/j.immuni.2009.08.002 View journal details

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