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PMID: 19666510 Published · ppublish English Journal Article Research Support, N.I.H., Intramural

IL-1 family members and STAT activators induce cytokine production by Th2, Th17, and Th1 cells.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 106 ·No. 32 ·2009-08-11 ·Pages 13463-8

Guo L, Wei G, Zhu J, Liao W, Leonard WJ, Zhao K, Paul W

Abstract

Expression of T1ST2, the IL-33R, by Th2 cells requires GATA3. Resting Th2 cells express little GATA3, which is increased by IL-33 and a STAT5 activator, in turn increasing T1ST2 from its low-level expression on resting Th2 cells. Th2 cells that have upregulated T1ST2 produce IL-13, but not IL-4, in response to IL-33 plus a STAT5 activator in an antigen-independent, NF-kappaB-dependent, cyclosporin A (CsA)-resistant manner. Similarly, Th17 cells produce IL-17A in response to IL-1beta and a STAT3 activator and Th1 cells produce IFNgamma in response to IL-18 and a STAT4 inducer. Thus, each effector Th cell produces cytokines without antigenic stimulation in response to an IL-1 family member and a specific STAT activator, implying an innate mechanism through which memory CD4 T cells are recruited by an induced cytokine environment.

MeSH Terms
Animals Cells, Cultured Cytokines/biosynthesis GATA3 Transcription Factor/metabolism Interleukin-1/metabolism Interleukin-13/metabolism Interleukin-17/metabolism Interleukin-2/biosynthesis Interleukin-33 Interleukin-4/metabolism Interleukins/metabolism Mice NF-kappa B/metabolism NFATC Transcription Factors/metabolism Phosphorylation Receptors, Antigen, T-Cell/metabolism Receptors, Interleukin-1/metabolism STAT Transcription Factors/metabolism STAT5 Transcription Factor/metabolism Th1 Cells/metabolism Th2 Cells/metabolism Up-Regulation p38 Mitogen-Activated Protein Kinases/metabolism
Chemicals
Cytokines GATA3 Transcription Factor Il33 protein, mouse Interleukin-1 Interleukin-13 Interleukin-17 Interleukin-2 Interleukin-33 Interleukins NF-kappa B NFATC Transcription Factors Receptors, Antigen, T-Cell Receptors, Interleukin-1 STAT Transcription Factors STAT5 Transcription Factor Interleukin-4 p38 Mitogen-Activated Protein Kinases
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Guo Liying
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Wei Gang
Zhu Jinfang
Liao Wei
Leonard Warren J
Zhao Keji
Paul William
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
1091-6490
DOI
10.1073/pnas.0906988106
Published
2009-08-11
Epub
2009-00-29
Pages
13463-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC2726336
Subset
IM
Grants
Intramural NIH HHS · United States
External Links
PubMed source DOI: 10.1073/pnas.0906988106 PMC Full Text View journal details
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