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PMID: 19661449 Published · ppublish English Journal Article Randomized Controlled Trial Research Support, N.I.H., Extramural

Adenosine receptor antagonist and augmented vasodilation during hypoxic exercise.

Journal of applied physiology (Bethesda, Md. : 1985) ·Vol. 107 ·No. 4 ·2009-10-00 ·Pages 1128-37

Casey DP, Madery BD, Pike TL, Eisenach JH, Dietz NM, Joyner MJ, Wilkins BW

Abstract

We tested the hypothesis that adenosine contributes to augmented skeletal muscle vasodilation during hypoxic exercise. In separate protocols, subjects performed incremental rhythmic forearm exercise (10% and 20% of maximum) during normoxia and normocapnic hypoxia (80% arterial O2 saturation). In protocol 1 (n = 8), subjects received an intra-arterial administration of saline (control) and aminophylline (adenosine receptor antagonist). In protocol 2 (n = 10), subjects received intra-arterial phentolamine (alpha-adrenoceptor antagonist) and combined phentolamine and aminophylline administration. Forearm vascular conductance (FVC; in ml x min(-1).100 mmHg(-1)) was calculated from forearm blood flow (in ml/min) and blood pressure (in mmHg). In protocol 1, the change in FVC (DeltaFVC; change from normoxic baseline) during hypoxic exercise with saline was 172 +/- 29 and 314 +/- 34 ml x min(-1) x 100 mmHg(-1) (10% and 20%, respectively). Aminophylline administration did not affect DeltaFVC during hypoxic exercise at 10% (190 +/- 29 ml x min(-1)x100 mmHg(-1), P = 0.4) or 20% (287 +/- 48 ml x min(-1) x 100 mmHg(-1), P = 0.3). In protocol 2, DeltaFVC due to hypoxic exercise with phentolamine infusion was 313 +/- 30 and 453 +/- 41 ml x min(-1) x 100 mmHg(-1) (10% and 20% respectively). DeltaFVC was similar at 10% (352 +/- 39 ml min(-1) x 100 mmHg(-1), P = 0.8) and 20% (528 +/- 45 ml x min(-1) x 100 mmHg(-1), P = 0.2) hypoxic exercise with combined phentolamine and aminophylline. In contrast, DeltaFVC to exogenous adenosine was reduced by aminophylline administration in both protocols (P < 0.05 for both). These observations suggest that adenosine receptor activation is not obligatory for the augmented hyperemia during hypoxic exercise in humans.

MeSH Terms
Adenosine/metabolism Adrenergic alpha-Antagonists/pharmacology Adult Aminophylline/administration & dosage,pharmacology Blood Flow Velocity/drug effects Blood Pressure/drug effects Brachial Artery/diagnostic imaging,drug effects,metabolism,physiopathology Exercise Female Forearm Hand Strength Heart Rate/drug effects Humans Hyperemia/diagnostic imaging,metabolism,physiopathology Hypoxia/diagnostic imaging,metabolism,physiopathology Infusions, Intra-Arterial Laser-Doppler Flowmetry Muscle, Skeletal/blood supply Oxygen/blood Phentolamine/pharmacology Pulmonary Ventilation/drug effects Purinergic P1 Receptor Antagonists Receptors, Purinergic P1/metabolism Regional Blood Flow/drug effects Sympathetic Nervous System/drug effects,physiopathology Ultrasonography Vasodilation/drug effects
Chemicals
Adrenergic alpha-Antagonists Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 Aminophylline Adenosine Oxygen Phentolamine
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Casey Darren P
Department of Anesthesiology, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA. casey.darren@mayo.edu
Madery Brandon D
Pike Tasha L
Eisenach John H
Dietz Niki M
Joyner Michael J
Wilkins Brad W
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Article Info
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
Abbr.
J Appl Physiol (1985)
ISSN
1522-1601
Published
2009-10-00
Epub
2009-00-06
Pages
1128-37
Language
English
Region
United States
NLM ID
8502536
PMCID
PMC2763830
Subset
IM
Grants
NIAMS NIH HHS · AR-55819 · United States
NHLBI NIH HHS · HL-46493 · United States
NHLBI NIH HHS · HL-78019 · United States
NCRR NIH HHS · RR-024150 · United States
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