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PMID: 19660870 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Harnessing the fruits of nature for the development of multi-targeted cancer therapeutics.

Cancer treatment reviews ·Vol. 35 ·No. 7 ·2009-11-00 ·Pages 597-607

Sarkar FH, Li Y

Abstract

Cancer cells exhibit deregulation in multiple cellular signaling pathways. Therefore, treatments using specific agents that target only one pathway usually fail in cancer therapy. The combination treatments using chemotherapeutic agents with distinct molecular mechanisms are considered more promising for higher efficacy; however, using multiple agents contributes to added toxicity. Emerging evidence has shown that some "natural products" such as isoflavones, indole-3-carbinol (I3C) and its in vivo dimeric product 3,3'-diindolylmethane (DIM), and curcumin among many others, have growth inhibitory and apoptosis inducing effects on human and animal cancer cells mediated by targeting multiple cellular signaling pathways in vitro without causing unwanted toxicity in normal cells. Therefore, these non-toxic "natural products" from natural resources could be useful in combination with conventional chemotherapeutic agents for the treatment of human malignancies with lower toxicity and higher efficacy. In fact, recently increasing evidence from pre-clinical in vivo studies and clinical trials have shown some success in support of the use of rational design of multi-targeted therapies for the treatment of cancers using conventional chemotherapeutic agents in combination with "natural products". These studies have provided promising results and further opened-up newer avenues for cancer therapy. In this review article, we have succinctly summarized the known effects of "natural products" especially by focusing on isoflavones, indole-3-carbinol (I3C) and its in vivo dimeric product 3,3'-diindolylmethane (DIM), and curcumin, and provided a comprehensive view on the molecular mechanisms underlying the principle of cancer therapy using combination of "natural products" with conventional therapeutics.

MeSH Terms
Animals Antineoplastic Agents/pharmacology Biological Products/pharmacology,therapeutic use Curcumin/pharmacology Humans Indoles/pharmacology Isoflavones/pharmacology Neoplasms/drug therapy
Chemicals
Antineoplastic Agents Biological Products Indoles Isoflavones indole-3-carbinol Curcumin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sarkar Fazlul H
Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Li Yiwei
References (112)
112 references, click to expand
  1. Indole-3-carbinol (I3C) induced cell growth inhibition, G1 cell cycle arrest and apoptosis in prostate cancer cells.
    Oncogene. 2001 May 24;20(23):2927-36 PMID: 11420705
  2. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK.
    Cancer Biol Ther. 2007 Feb;6(2):178-84 PMID: 17218783
  3. The chemopreventive properties of soy isoflavonoids in animal models of breast cancer.
    Breast Cancer Res Treat. 1997 Nov-Dec;46(2-3):169-79 PMID: 9478272
  4. Genistein inhibits NF-kappa B activation in prostate cancer cells.
    Nutr Cancer. 1999;35(2):167-74 PMID: 10693171
  5. Anticarcinogenic activity of indole-3-carbinol acid products: ultrasensitive bioassay by trout embryo microinjection.
    Cancer Res. 1994 Jul 1;54(13):3617-9 PMID: 8012989
  6. Curcumin attenuates DNB-induced murine colitis.
    Am J Physiol Gastrointest Liver Physiol. 2003 Jul;285(1):G235-43 PMID: 12637253
  7. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products.
    Clin Cancer Res. 2008 Apr 1;14(7):2128-36 PMID: 18381954
  8. Cellular signaling perturbation by natural products.
    Cell Signal. 2009 Nov;21(11):1541-7 PMID: 19298854
  9. Down-regulation of Notch-1 contributes to cell growth inhibition and apoptosis in pancreatic cancer cells.
    Mol Cancer Ther. 2006 Mar;5(3):483-93 PMID: 16546962
  10. Gene expression profiles of I3C- and DIM-treated PC3 human prostate cancer cells determined by cDNA microarray analysis.
    J Nutr. 2003 Apr;133(4):1011-9 PMID: 12672912
  11. Indole-3-carbinol (I3C) exhibits inhibitory and preventive effects on prostate tumors in mice.
    Food Chem Toxicol. 2008 Mar;46(3):863-70 PMID: 18063461
  12. Akt inactivation is a key event in indole-3-carbinol-induced apoptosis in PC-3 cells.
    Clin Cancer Res. 2002 Apr;8(4):1228-36 PMID: 11948137
  13. New difluoro Knoevenagel condensates of curcumin, their Schiff bases and copper complexes as proteasome inhibitors and apoptosis inducers in cancer cells.
    Pharm Res. 2009 Aug;26(8):1874-80 PMID: 19421843
  14. Urinary phytoestrogen excretion and breast cancer risk: evaluating potential effect modifiers endogenous estrogens and anthropometrics.
    Cancer Epidemiol Biomarkers Prev. 2003 Jun;12(6):497-502 PMID: 12814993
  15. Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.
    Cancer Res. 2007 Jul 1;67(13):6502-11 PMID: 17616712
  16. Soybean isoflavones reduce experimental metastasis in mice.
    J Nutr. 1999 May;129(5):1075-8 PMID: 10222402
  17. Liposome-encapsulated curcumin suppresses growth of head and neck squamous cell carcinoma in vitro and in xenografts through the inhibition of nuclear factor kappaB by an AKT-independent pathway.
    Clin Cancer Res. 2008 Oct 1;14(19):6228-36 PMID: 18829502
  18. Curcumin exerts multiple suppressive effects on human breast carcinoma cells.
    Int J Cancer. 2002 Mar 10;98(2):234-40 PMID: 11857414
  19. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.
    Biochem Pharmacol. 2008 Dec 1;76(11):1590-611 PMID: 18775680
  20. Soy protein containing isoflavones does not decrease colorectal epithelial cell proliferation in a randomized controlled trial.
    Am J Clin Nutr. 2005 Sep;82(3):620-6 PMID: 16155276
  21. Effects of curcumin on N-bis(2-hydroxypropyl) nitrosamine (DHPN)-induced lung and liver tumorigenesis in BALB/c mice in vivo.
    In Vivo. 2008 Nov-Dec;22(6):781-5 PMID: 19181006
  22. Effects of dietary indole-3-carbinol on estradiol metabolism and spontaneous mammary tumors in mice.
    Carcinogenesis. 1991 Sep;12(9):1571-4 PMID: 1893517
  23. Curcumin down-regulates AR gene expression and activation in prostate cancer cell lines.
    Int J Oncol. 2002 Oct;21(4):825-30 PMID: 12239622
  24. Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary.
    Nutr J. 2008 Jun 03;7:17 PMID: 18522734
  25. Phase II trial of isoflavone in prostate-specific antigen recurrent prostate cancer after previous local therapy.
    BMC Cancer. 2008 May 11;8:132 PMID: 18471323
  26. Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells.
    Biochem Pharmacol. 2003 Feb 1;65(3):361-76 PMID: 12527329
  27. Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids.
    Cancer Lett. 1999 Nov 15;146(2):161-7 PMID: 10656621
  28. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.
    Mol Cancer Ther. 2008 Sep;7(9):2609-20 PMID: 18790744
  29. Effects of a soybean isoflavone mixture on carcinogenesis in prostate and seminal vesicles of F344 rats.
    Jpn J Cancer Res. 1999 Apr;90(4):393-8 PMID: 10363576
  30. Therapeutic activity of 3,3'-diindolylmethane on prostate cancer in an in vivo model.
    Prostate. 2004 Oct 1;61(2):153-60 PMID: 15305338
  31. Lycopene and soy isoflavones in the treatment of prostate cancer.
    Nutr Cancer. 2007;59(1):1-7 PMID: 17927495
  32. Soy isoflavone supplementation in healthy men prevents NF-kappa B activation by TNF-alpha in blood lymphocytes.
    Free Radic Biol Med. 2001 Jun 1;30(11):1293-302 PMID: 11368927
  33. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer.
    Am J Transl Res. 2010 Jul 23;2(4):402-11 PMID: 20733950
  34. Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy.
    Acta Pharmacol Sin. 2007 Sep;28(9):1305-15 PMID: 17723164
  35. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.
    Cancer Lett. 2008 Oct 8;269(2):199-225 PMID: 18479807
  36. Inhibition of nuclear factor kappab activity by genistein is mediated via Notch-1 signaling pathway in pancreatic cancer cells.
    Int J Cancer. 2006 Apr 15;118(8):1930-6 PMID: 16284950
  37. Expression of prostate-specific antigen is transcriptionally regulated by genistein in prostate cancer cells.
    Mol Carcinog. 2002 Jun;34(2):91-101 PMID: 12112315
  38. Chemoprevention of aflatoxin B1-induced carcinogenesis by indole-3-carbinol in rat liver--predicting the outcome using early biomarkers.
    Carcinogenesis. 1998 Oct;19(10):1829-36 PMID: 9806166
  39. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo.
    Cancer Res. 2008 Sep 15;68(18):7283-92 PMID: 18794115
  40. Cancer chemoprevention with dietary phytochemicals.
    Nat Rev Cancer. 2003 Oct;3(10):768-80 PMID: 14570043
  41. Soy and isoflavone consumption in relation to prostate cancer risk in China.
    Cancer Epidemiol Biomarkers Prev. 2003 Jul;12(7):665-8 PMID: 12869409
  42. Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.
    Arch Biochem Biophys. 1998 Apr 1;352(1):59-70 PMID: 9521814
  43. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets.
    J Immunol. 2005 Jun 15;174(12):8116-24 PMID: 15944320
  44. The specific role of isoflavones in reducing prostate cancer risk.
    Prostate. 2004 May 1;59(2):141-7 PMID: 15042614
  45. Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein.
    Nutr Cancer. 1993;20(1):1-12 PMID: 8415125
  46. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.
    Cancer Res. 2007 Apr 15;67(8):3853-61 PMID: 17440100
  47. Apoptosis-inducing effect of erlotinib is potentiated by 3,3'-diindolylmethane in vitro and in vivo using an orthotopic model of pancreatic cancer.
    Mol Cancer Ther. 2008 Jun;7(6):1708-19 PMID: 18566242
  48. Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin.
    Mol Cancer Ther. 2005 Feb;4(2):233-41 PMID: 15713895
  49. Expression profiling of rat mammary epithelial cells reveals candidate signaling pathways in dietary protection from mammary tumors.
    Physiol Genomics. 2007 Jun 19;30(1):8-16 PMID: 17341692
  50. Phase II trial of curcumin in patients with advanced pancreatic cancer.
    Clin Cancer Res. 2008 Jul 15;14(14):4491-9 PMID: 18628464
  51. Inhibition of angiogenesis and invasion by 3,3'-diindolylmethane is mediated by the nuclear factor-kappaB downstream target genes MMP-9 and uPA that regulated bioavailability of vascular endothelial growth factor in prostate cancer.
    Cancer Res. 2007 Apr 1;67(7):3310-9 PMID: 17409440
  52. 3,3'-Diindolylmethane inhibits angiogenesis and the growth of transplantable human breast carcinoma in athymic mice.
    Carcinogenesis. 2005 Apr;26(4):771-8 PMID: 15661811
  53. Inhibition of prostate specific antigen expression by genistein in prostate cancer cells.
    Int J Oncol. 2000 Jun;16(6):1091-7 PMID: 10811979
  54. Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells.
    J Biol Chem. 2007 Jul 20;282(29):21542-50 PMID: 17522055
  55. Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines.
    Oncogene. 2001 Nov 15;20(52):7597-609 PMID: 11753638
  56. TNF-alpha-induced cyclooxygenase-2 expression in human lung epithelial cells: involvement of the phospholipase C-gamma 2, protein kinase C-alpha, tyrosine kinase, NF-kappa B-inducing kinase, and I-kappa B kinase 1/2 pathway.
    J Immunol. 2000 Sep 1;165(5):2719-28 PMID: 10946303
  57. 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management.
    Neoplasia. 2003 May-Jun;5(3):255-66 PMID: 12869308
  58. Genistein, a specific inhibitor of tyrosine-specific protein kinases.
    J Biol Chem. 1987 Apr 25;262(12):5592-5 PMID: 3106339
  59. A pilot clinical study of short-term isoflavone supplements in breast cancer patients.
    Nutr Cancer. 2004;49(1):59-65 PMID: 15456636
  60. Dietary genistein down-regulates androgen and estrogen receptor expression in the rat prostate.
    Mol Cell Endocrinol. 2002 Jan 15;186(1):89-99 PMID: 11850125
  61. Soy isoflavone genistein upregulates epithelial adhesion molecule E-cadherin expression and attenuates beta-catenin signaling in mammary epithelial cells.
    Carcinogenesis. 2009 Feb;30(2):331-9 PMID: 19073877
  62. Mammalian target of rapamycin repression by 3,3'-diindolylmethane inhibits invasion and angiogenesis in platelet-derived growth factor-D-overexpressing PC3 cells.
    Cancer Res. 2008 Mar 15;68(6):1927-34 PMID: 18339874
  63. Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells.
    Cancer Res. 2005 Aug 1;65(15):6934-42 PMID: 16061678
  64. Potency of dietary indole-3-carbinol as a promoter of aflatoxin B1-initiated hepatocarcinogenesis: results from a 9000 animal tumor study.
    Carcinogenesis. 1999 Mar;20(3):453-8 PMID: 10190561
  65. Plant-derived 3,3'-Diindolylmethane is a strong androgen antagonist in human prostate cancer cells.
    J Biol Chem. 2003 Jun 6;278(23):21136-45 PMID: 12665522
  66. The specific role of isoflavones on estrogen metabolism in premenopausal women.
    Cancer. 2002 Feb 15;94(4):1166-74 PMID: 11920488
  67. Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration.
    Br J Cancer. 2004 Mar 8;90(5):1011-5 PMID: 14997198
  68. Plasma isoflavones and fibrocystic breast conditions and breast cancer among women in Shanghai, China.
    Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2579-86 PMID: 18086761
  69. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects.
    Cancer Epidemiol Biomarkers Prev. 2008 Oct;17(10):2619-24 PMID: 18843002
  70. Inhibitory effects of soy and rye diets on the development of Dunning R3327 prostate adenocarcinoma in rats.
    Prostate. 1998 Aug 1;36(3):151-61 PMID: 9687986
  71. Indole-3-carbinol and beta-naphthoflavone induction of aflatoxin B1 metabolism and cytochromes P-450 associated with bioactivation and detoxication of aflatoxin B1 in the rat.
    Drug Metab Dispos. 1994 May-Jun;22(3):383-91 PMID: 8070314
  72. Chemoprevention of spontaneous endometrial cancer in female Donryu rats by dietary indole-3-carbinol.
    Cancer Res. 1994 Mar 15;54(6):1446-9 PMID: 8137246
  73. Evaluation of chemopreventive agents for genotoxic activity.
    Mutat Res. 2007 May 18;629(2):148-60 PMID: 17387038
  74. Beta-catenin-mediated transactivation and cell-cell adhesion pathways are important in curcumin (diferuylmethane)-induced growth arrest and apoptosis in colon cancer cells.
    Oncogene. 2002 Dec 5;21(55):8414-27 PMID: 12466962
  75. Genistein.
    Phytochemistry. 2002 Jun;60(3):205-11 PMID: 12031439
  76. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice.
    J Nutr. 1999 Sep;129(9):1628-35 PMID: 10460196
  77. Selective growth regulatory and pro-apoptotic effects of DIM is mediated by AKT and NF-kappaB pathways in prostate cancer cells.
    Front Biosci. 2005 Jan 01;10:236-43 PMID: 15574364
  78. Cancer statistics, 2008.
    CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96 PMID: 18287387
  79. Inactivation of NF-kappaB by genistein is mediated via Akt signaling pathway in breast cancer cells.
    Oncogene. 2003 Jul 24;22(30):4702-9 PMID: 12879015
  80. Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats.
    J Steroid Biochem Mol Biol. 1992 Nov;43(6):557-64 PMID: 1419891
  81. Inhibition of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin.
    Carcinogenesis. 2002 Aug;23(8):1307-13 PMID: 12151348
  82. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents.
    J Med Chem. 2002 Nov 7;45(23):5037-42 PMID: 12408714
  83. Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences.
    Cancer Epidemiol Biomarkers Prev. 2005 Jan;14(1):120-5 PMID: 15668484
  84. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer.
    Urology. 2004 Feb;63(2):259-63 PMID: 14972467
  85. Apoptosis by dietary factors: the suicide solution for delaying cancer growth.
    Carcinogenesis. 2007 Feb;28(2):233-9 PMID: 17151090
  86. Down-regulation of androgen receptor by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in both hormone-sensitive LNCaP and insensitive C4-2B prostate cancer cells.
    Cancer Res. 2006 Oct 15;66(20):10064-72 PMID: 17047070
  87. A review of mechanisms underlying anticarcinogenicity by brassica vegetables.
    Chem Biol Interact. 1997 Feb 28;103(2):79-129 PMID: 9055870
  88. Soy isoflavones in the treatment of prostate cancer.
    Nutr Cancer. 2003;47(2):111-7 PMID: 15087261
  89. Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis.
    Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8 PMID: 16757216
  90. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300.
    Biochem Biophys Res Commun. 2008 Dec 26;377(4):1304-8 PMID: 19000900
  91. Clinical trials of natural products as chemopreventive agents for prostate cancer.
    Expert Opin Investig Drugs. 2006 Oct;15(10):1191-200 PMID: 16989596
  92. Effect of nutritional supplement challenge in patients with isolated high-grade prostatic intraepithelial neoplasia.
    Urology. 2007 Jun;69(6):1102-6 PMID: 17572195
  93. A phase I study of indole-3-carbinol in women: tolerability and effects.
    Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1953-60 PMID: 16103443
  94. Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions.
    Anticancer Res. 2001 Jul-Aug;21(4B):2895-900 PMID: 11712783
  95. Genistein suppresses mammary cancer in rats.
    Carcinogenesis. 1995 Nov;16(11):2833-40 PMID: 7586206
  96. Biotherapy of B-cell precursor leukemia by targeting genistein to CD19-associated tyrosine kinases.
    Science. 1995 Feb 10;267(5199):886-91 PMID: 7531365
  97. Effect of dietary indole-3-carbinol on intestinal and hepatic monooxygenase, glutathione S-transferase and epoxide hydrolase activities in the rat.
    Food Chem Toxicol. 1984 Dec;22(12):977-82 PMID: 6334634
  98. A randomized phase II trial of indole-3-carbinol in the treatment of vulvar intraepithelial neoplasia.
    Int J Gynecol Cancer. 2006 Mar-Apr;16(2):786-90 PMID: 16681761
  99. Molecular mechanisms of curcumin-induced cytotoxicity: induction of apoptosis through generation of reactive oxygen species, down-regulation of Bcl-XL and IAP, the release of cytochrome c and inhibition of Akt.
    Carcinogenesis. 2003 Jul;24(7):1199-208 PMID: 12807727
  100. Regulation of Akt/FOXO3a/GSK-3beta/AR signaling network by isoflavone in prostate cancer cells.
    J Biol Chem. 2008 Oct 10;283(41):27707-27716 PMID: 18687691
  101. Down-regulation of invasion and angiogenesis-related genes identified by cDNA microarray analysis of PC3 prostate cancer cells treated with genistein.
    Cancer Lett. 2002 Dec 5;186(2):157-64 PMID: 12213285
  102. Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial.
    Cancer Epidemiol Biomarkers Prev. 2004 Apr;13(4):644-8 PMID: 15066931
  103. Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via Akt signaling pathway.
    Clin Cancer Res. 2002 Jul;8(7):2369-77 PMID: 12114442
  104. Isoflavone-rich soy protein isolate suppresses androgen receptor expression without altering estrogen receptor-beta expression or serum hormonal profiles in men at high risk of prostate cancer.
    J Nutr. 2007 Jul;137(7):1769-75 PMID: 17585029
  105. Phase I clinical trial of oral curcumin: biomarkers of systemic activity and compliance.
    Clin Cancer Res. 2004 Oct 15;10(20):6847-54 PMID: 15501961
  106. Dietary flavonoids and colorectal adenoma recurrence in the Polyp Prevention Trial.
    Cancer Epidemiol Biomarkers Prev. 2008 Jun;17(6):1344-53 PMID: 18559549
  107. Potent ligand-independent estrogen receptor activation by 3,3'-diindolylmethane is mediated by cross talk between the protein kinase A and mitogen-activated protein kinase signaling pathways.
    Mol Endocrinol. 2004 Feb;18(2):291-302 PMID: 14645498
  108. Curcumin suppresses constitutive activation of nuclear factor-kappa B and requires functional Bax to induce apoptosis in Burkitt's lymphoma cell lines.
    Mol Cancer Ther. 2008 Oct;7(10):3318-29 PMID: 18852135
  109. Phytoestrogen interaction with estrogen receptors in human breast cancer cells.
    Endocrinology. 1978 Nov;103(5):1860-7 PMID: 570914
  110. Indole-3-carbinol for recurrent respiratory papillomatosis: long-term results.
    J Voice. 2004 Jun;18(2):248-53 PMID: 15193659
  111. Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
    Blood. 2003 Feb 1;101(3):1053-62 PMID: 12393461
  112. Fruits, vegetables and lung cancer: a pooled analysis of cohort studies.
    Int J Cancer. 2003 Dec 20;107(6):1001-11 PMID: 14601062
Article Info
Journal
Cancer treatment reviews
Abbr.
Cancer Treat Rev
ISSN
1532-1967
DOI
10.1016/j.ctrv.2009.07.001
Published
2009-11-00
Epub
2009-00-05
Pages
597-607
Language
English
Region
Netherlands
NLM ID
7502030
PMCID
PMC2784186
Subset
IM
Grants
NCI NIH HHS · R01 CA131151 · United States
NCI NIH HHS · R01 CA101870-05 · United States
NCI NIH HHS · 5R01CA108535 · United States
NCI NIH HHS · R01 CA108535 · United States
NCI NIH HHS · 5R01CA083695 · United States
NCI NIH HHS · R01 CA101870 · United States
NCI NIH HHS · R01 CA131151-02 · United States
NCI NIH HHS · R01 CA132794-01A1 · United States
NCI NIH HHS · 5R01CA101870 · United States
NCI NIH HHS · R01 CA083695-07 · United States
NCI NIH HHS · R01 CA132794 · United States
NCI NIH HHS · R01 CA083695 · United States
External Links
PubMed source DOI: 10.1016/j.ctrv.2009.07.001 PMC Full Text View journal details
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