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PMID: 1963293 Published · ppublish English Journal Article

Poliovirus-mediated entry of pokeweed antiviral protein.

Antimicrobial agents and chemotherapy ·Vol. 34 ·No. 10 ·1990-10-00 ·Pages 2034-7

Lee T, Crowell M, Shearer MH, Aron GM, Irvin JD

Abstract

Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. Cell permeabilization was dependent on the integrity of virus capsid proteins and directly proportional to the multiplicity of infection. This study demonstrates that virus adsorption is sufficient for the entry of pokeweed antiviral protein into poliovirus-infected cells.

MeSH Terms
Antiviral Agents/pharmacology Cell Membrane Permeability/drug effects HeLa Cells N-Glycosyl Hydrolases Plant Proteins/pharmacology Poliovirus/drug effects Ribosome Inactivating Proteins, Type 1 Viral Proteins/biosynthesis
Chemicals
Antiviral Agents Plant Proteins Ribosome Inactivating Proteins, Type 1 Viral Proteins N-Glycosyl Hydrolases pokeweed antiviral protein
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Lee T
Department of Biology, Southwest Texas State University, San Marcos 78666.
Crowell M
Shearer M H
Aron G M
Irvin J D
References (18)
18 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.34.10.2034
Published
1990-10-00
Pages
2034-7
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC171988
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.34.10.2034 PMC Full Text View journal details
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