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题目:: A dynamic map of antigen recognition by CD4 T cells at the site of Leishmania major infection.
作者:: Filipe-Santos(Orchidée),Pescher(Pascale),Breart(Béatrice),Lippuner(Christoph),Aebischer(Toni),Glaichenhaus(Nicolas),Späth(Gerald F),Bousso(Philippe)
状态:: 发布时间2009-07-20 , 更新时间 2009-07-20
期刊:: Cell Host Microbe
摘要:: CD4 T helper cells play a central role in the control of infection by intracellular parasites. How efficiently pathogen-specific CD4 T cells detect infected cells in vivo is unclear. Here, we employed intravital two-photon imaging to examine the behavior of pathogen-specific CD4 T cells at the site of Leishmania major infection. While activated CD4 T cells enter the inflamed tissue irrespective of their antigen specificity, pathogen-specific T cells preferentially decelerated and accumulated in infected regions of the dermis. Antigen recognition by CD4 T cells was heterogeneous, involving both stable and dynamic contacts with infected phagocytes. However, not all infected cells induced arrest or deceleration of pathogen-specific T cells, and dense clusters of infected cells were poorly accessible to migrating T cells. Thus, disparities in the dynamics of T cell contacts with infected cells and local variation in T cell access to infected cells are important elements of the host-pathogen interplay.
语言:: eng
DOI:: 10.1016/j.chom.2009.04.014

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