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PMID: 19597371 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Mechanosensitive channels in striated muscle and the cardiovascular system: not quite a stretch anymore.

Journal of cardiovascular pharmacology ·Vol. 54 ·No. 2 ·2009-08-00 ·Pages 116-22

Stiber JA, Seth M, Rosenberg PB

Abstract

Stretch-activated or mechanosensitive channels transduce mechanical forces into ion fluxes across the cell membrane. These channels have been implicated in several aspects of cardiovascular physiology including regulation of blood pressure, vasoreactivity, and cardiac arrhythmias, as well as the adverse remodeling associated with cardiac hypertrophy and heart failure. This review discusses mechanosensitive channels in skeletal muscle and the cardiovascular system and their role in disease pathogenesis. We describe the regulation of gating of mechanosensitive channels including direct mechanisms and indirect activation by signaling pathways, as well as the influence on activation of these channels by the underlying cytoskeleton and scaffolding proteins. We then focus on the role of transient receptor potential channels, several of which have been implicated as mechanosensitive channels, in the pathogenesis of adverse cardiac remodeling and as potential therapeutic targets in the treatment of heart failure.

MeSH Terms
Animals Cardiovascular Diseases/drug therapy,physiopathology Cardiovascular System/metabolism,physiopathology Cytoskeleton/physiology Drug Delivery Systems Heart Failure/drug therapy,physiopathology Humans Ion Channels/physiology Muscle, Skeletal/physiology Signal Transduction Transient Receptor Potential Channels/metabolism
Chemicals
Ion Channels Transient Receptor Potential Channels
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Stiber Jonathan A
Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Seth Malini
Rosenberg Paul B
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Article Info
Journal
Journal of cardiovascular pharmacology
Abbr.
J Cardiovasc Pharmacol
ISSN
1533-4023
DOI
10.1097/FJC.0b013e3181aa233f
Published
2009-08-00
Pages
116-22
Language
English
Region
United States
NLM ID
7902492
PMCID
PMC4280092
Subset
IM
Grants
NHLBI NIH HHS · K08-HL077520 · United States
NHLBI NIH HHS · K08 HL077520 · United States
NHLBI NIH HHS · K08 HL071841 · United States
NHLBI NIH HHS · R01 HL093470 · United States
NHLBI NIH HHS · K08-HL-071841-04 · United States
External Links
PubMed source DOI: 10.1097/FJC.0b013e3181aa233f PMC Full Text View journal details
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