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PMID: 19585625 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Molecular mechanism of inhibition of the human protein complex Hsp90-Cdc37, a kinome chaperone-cochaperone, by triterpene celastrol.

Angewandte Chemie (International ed. in English) ·Vol. 48 ·No. 32 ·2009-00-00 ·Pages 5853-5

Sreeramulu S, Gande SL, Göbel M, Schwalbe H

Abstract

暂无摘要

MeSH Terms
Binding Sites Cell Cycle Proteins/antagonists & inhibitors,metabolism Chaperonins/antagonists & inhibitors,metabolism HSP90 Heat-Shock Proteins/antagonists & inhibitors,metabolism Humans Pentacyclic Triterpenes Protein Folding Triterpenes/chemistry,pharmacology
Chemicals
CDC37 protein, human Cell Cycle Proteins HSP90 Heat-Shock Proteins Pentacyclic Triterpenes Triterpenes Chaperonins celastrol
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Sreeramulu Sridhar
Johann Wolfgang Goethe-University, Frankfurt am Main, Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Max-von-Laue-Strasse 7, 60438 Frankfurt am Main, Germany.
Gande Santosh Lakshmi
Göbel Michael
Schwalbe Harald
Article Info
Journal
Angewandte Chemie (International ed. in English)
Abbr.
Angew Chem Int Ed Engl
ISSN
1521-3773
DOI
10.1002/anie.200900929
Published
2009-00-00
Pages
5853-5
Language
English
Region
Germany
NLM ID
0370543
Subset
IM
External Links
PubMed source DOI: 10.1002/anie.200900929 View journal details
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