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题目:: The role of caveolin-1 in prostate cancer: clinical implications.
作者:: Thompson(T C),Tahir(S A),Li(L),Watanabe(M),Naruishi(K),Yang(G),Kadmon(D),Logothetis(C J),Troncoso(P),Ren(C),Goltsov(A),Park(S)
状态:: 发布时间2010-02-10 , 更新时间 2016-11-22
期刊:: Prostate Cancer Prostatic Dis
摘要:: Caveolin-1 (cav-1) is reportedly overexpressed in prostate cancer cells and is associated with disease progression. Specific oncogenic activities of cav-1 associated with Akt activation also occur in prostate cancer. A membrane-associated protein, cav-1, is nonetheless secreted by prostate cancer cells; results of recent studies showed that secreted cav-1 can stimulate cell survival and angiogenic activities, defining a role for cav-1 in the prostate cancer microenvironment. Serum cav-1 levels were also higher in prostate cancer patients than in control men without prostate cancer, and the preoperative serum cav-1 concentration had prognostic potential in men undergoing radical prostatectomy. Secreted cav-1 is therefore a potential biomarker and therapeutic target for prostate cancer.
语言:: eng
DOI:

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