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PMID: 195581 Published · ppublish English Journal Article

Phosphatidylinositol-degrading enzymes in liver lysosomes.

The Biochemical journal ·Vol. 164 ·No. 1 ·1977-04-15 ·Pages 277-80

Irvine RF, Hemington N, Dawson RM

Abstract

The major pathway by which liver lysosomal enzymes degrade phosphatidylinositol is through an EDTA-insensitive formation of phosphorylinositol. This is in distinct contrast with the Ca2+-dependent production of phosphorylinositol from phosphatidylinositol, which is located in the cytosol. Lysosomal enzymes can also totally deacylate phosphatidylinositol, producing glycerophosphorylinositol.

MeSH Terms
Acid Phosphatase/metabolism Animals Electron Transport Complex IV/metabolism Glucose-6-Phosphatase/metabolism L-Lactate Dehydrogenase/metabolism Liver/enzymology Lysosomes/enzymology Nucleotidases/metabolism Phosphatidylinositols/metabolism Rats
Chemicals
Phosphatidylinositols L-Lactate Dehydrogenase Electron Transport Complex IV Nucleotidases Acid Phosphatase Glucose-6-Phosphatase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Irvine R F
Hemington N
Dawson R M
References (23)
23 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1640277
Published
1977-04-15
Pages
277-80
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1164785
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1640277 PMC Full Text View journal details
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