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PMID: 19553672 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Complex glycan catabolism by the human gut microbiota: the Bacteroidetes Sus-like paradigm.

The Journal of biological chemistry ·Vol. 284 ·No. 37 ·2009-09-11 ·Pages 24673-7

Martens EC, Koropatkin NM, Smith TJ, Gordon JI

Abstract

Trillions of microbes inhabit the distal gut of adult humans. They have evolved to compete efficiently for nutrients, including a wide array of chemically diverse, complex glycans present in our diets, secreted by our intestinal mucosa, and displayed on the surfaces of other gut microbes. Here, we review how members of the Bacteroidetes, one of two dominant gut-associated bacterial phyla, process complex glycans using a series of similarly patterned, cell envelope-associated multiprotein systems. These systems provide insights into how gut, as well as terrestrial and aquatic, Bacteroidetes survive in highly competitive ecosystems.

MeSH Terms
Bacteroidetes/metabolism Catalysis Cellulose/chemistry Gene Expression Profiling Gene Expression Regulation, Bacterial Genome, Bacterial Humans Intestines/microbiology Metabolic Networks and Pathways/genetics Models, Biological Models, Genetic Polysaccharides/chemistry,metabolism Starch/chemistry
Chemicals
Polysaccharides Cellulose Starch
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Martens Eric C
Center for Genome Sciences, Washington University School of Medicine, St. Louis, Missouri 63108, USA.
Koropatkin Nicole M
Smith Thomas J
Gordon Jeffrey I
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Article Info
Journal
The Journal of biological chemistry
Abbr.
J Biol Chem
ISSN
1083-351X
DOI
10.1074/jbc.R109.022848
Published
2009-09-11
Epub
2009-00-24
Pages
24673-7
Language
English
Region
United States
NLM ID
2985121R
PMCID
PMC2757170
Subset
IM
Grants
NICHD NIH HHS · HD07409 · United States
NIDDK NIH HHS · R01 DK030292 · United States
NIAID NIH HHS · F32 AI073060 · United States
NIGMS NIH HHS · F32 GM078800 · United States
NIDDK NIH HHS · DK30292 · United States
NIAID NIH HHS · AI073060 · United States
NICHD NIH HHS · T32 HD007409 · United States
NIDDK NIH HHS · R37 DK030292 · United States
NIGMS NIH HHS · GM078800 · United States
External Links
PubMed source DOI: 10.1074/jbc.R109.022848 PMC Full Text View journal details
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